What compounds affect the CYP2E1 reactions pathway?

501 compounds in the BiohacksAI corpus have documented interactions with genes in the CYP2E1 reactions pathway (Reactome ID: R-HSA-211999). These compounds target 8 genes within this pathway.

What genes are in the CYP2E1 reactions pathway?

The CYP2E1 reactions pathway involves 8 genes. Key genes include: CYP2A13, CYP2A6, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP2E1.

CYP2E1 reactions

REACTOME PATHWAY

Reactome: R-HSA-2119998 genes501 compounds

The CYP2E1 reactions pathway (Reactome ID: R-HSA-211999) involves 8 genes and is affected by 501 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CYP2A13 CYP2A6 CYP2B6 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1

Compounds Affecting CYP2E1 reactions

#	Compound	Targets Hit	Studies
1	Methoxsalen	—	300
2	Clotrimazole	—	296
3	Ethinyl Estradiol	—	300
4	Loratadine	—	296
5	Danazol	—	298
6	cbd	—	298
7	cannabidiol	—	296
8	Pilocarpine	—	297
9	Ritonavir	—	298
10	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	1,000
11	Simvastatin	—	1,000
12	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	293
13	Disulfiram	—	297
14	Isoniazid Antibacterial agent used primarily as	—	299
15	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
16	Quercetin	—	300
17	Finasteride	—	296
18	Flutamide	—	298
19	Rotenone	—	300
20	Carbaryl	—	300
21	Chlorhexidine	—	299
22	Cimetidine	—	299
23	Ethoxyquin Antioxidant; also	—	180
24	Vitamin K 3	—	300
25	Piribedil	—	300
26	Tolazamide	—	169
27	Progesterone	—	299
28	Colchicine	—	300
29	Lovastatin	—	300
30	Mestranol	—	300
31	Nisoldipine	—	297
32	Phenylbutazone	—	300
33	Phenytoin	—	300
34	Sulindac	—	297
35	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
36	Pueraria	—	300
37	Kaempferols	—	300
38	Melatonin	—	297
39	Methylene Blue	—	200
40	17 alpha-Hydroxyprogesterone Caproate Hydroxyprogesterone derivative that acts as	—	287
41	Celecoxib	—	295
42	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
43	Ethidium	—	300
44	Gemfibrozil	—	297
45	Glyburide	—	298
46	Hexachlorophene	—	300
47	Leflunomide	—	297
48	Melphalan	—	300
49	Miconazole	—	298
50	Noscapine	—	300

About the CYP2E1 reactions Pathway

The CYP2E1 reactions pathway is catalogued in Reactome (ID: R-HSA-211999) and involves 8 genes. In the BiohacksAI corpus, 501 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CYP2A13, CYP2A6, CYP2B6, CYP2C19, CYP2C8.