Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)

Q: What compounds affect the Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) pathway?

489 compounds in the BiohacksAI corpus have documented interactions with genes in the Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) pathway (Reactome ID: R-HSA-2142816). These compounds target 6 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-21428166 genes489 compounds

The Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) pathway (Reactome ID: R-HSA-2142816) involves 6 genes and is affected by 489 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CYP1A1 CYP1A2 CYP1B1 CYP2C19 CYP2C8 CYP2C9

Compounds Affecting Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
3	chrysin	—	300
4	Kaempferols	—	300
5	Hesperidin	—	300
6	cbd	—	298
7	cannabidiol	—	296
8	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
9	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
10	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
11	Clotrimazole	—	296
12	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
13	Gemfibrozil	—	297
14	Kaempferols	—	300
15	Disulfiram	—	297
16	Isoniazid Antibacterial agent used primarily as	—	299
17	Ethinyl Estradiol	—	300
18	Flutamide	—	298
19	Methoxsalen	—	300
20	Rotenone	—	300
21	Carbaryl	—	300
22	Chlorhexidine	—	299
23	Corticosterone	—	300
24	Ethoxyquin Antioxidant; also	—	180
25	Loratadine	—	296
26	Vitamin K 3	—	300
27	Piribedil	—	300
28	Tolazamide	—	169
29	Genistein	—	300
30	Progesterone	—	299
31	Fenofibrate	—	297
32	Mestranol	—	300
33	Nisoldipine	—	297
34	Sulindac	—	297
35	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
36	Pueraria	—	300
37	Melatonin	—	297
38	Methylene Blue	—	200
39	Vitamin	—	295
40	Anastrozole	—	298
41	Carboxin	—	174
42	Danazol	—	298
43	Ethidium	—	300
44	iodoform	—	272
45	Leflunomide	—	297
46	Linuron	—	299
47	Lynestrenol	—	299
48	Melphalan	—	300
49	Miconazole	—	298
50	Phenelzine	—	297

About the Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Pathway

The Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) pathway is catalogued in Reactome (ID: R-HSA-2142816) and involves 6 genes. In the BiohacksAI corpus, 489 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8.