What compounds affect the Abacavir ADME pathway?

176 compounds in the BiohacksAI corpus have documented interactions with genes in the Abacavir ADME pathway (Reactome ID: R-HSA-2161522). These compounds target 4 genes within this pathway.

What genes are in the Abacavir ADME pathway?

The Abacavir ADME pathway involves 4 genes. Key genes include: ABCB1, ABCG2, SLC22A1, SLC22A3.

Abacavir ADME

REACTOME PATHWAY

Reactome: R-HSA-21615224 genes176 compounds

The Abacavir ADME pathway (Reactome ID: R-HSA-2161522) involves 4 genes and is affected by 176 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCB1 ABCG2 SLC22A1 SLC22A3

Compounds Affecting Abacavir ADME

#	Compound	Targets Hit	Studies
1	Progesterone	—	299
2	Chlorhexidine	—	299
3	Quinidine	—	298
4	Carvedilol	—	296
5	Colchicine	—	300
6	Daunorubicin	—	298
7	Delavirdine	—	296
8	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
9	chrysin	—	300
10	Kaempferols	—	300
11	Quercetin	—	300
12	Sirolimus	—	300
13	Desoxycorticosterone	—	300
14	Dinoprostone	—	296
15	Pindolol	—	299
16	Corticosterone	—	300
17	Reserpine	—	297
18	Astemizole Antihistamine drug now withdrawn from	—	280
19	Clotrimazole	—	296
20	Testosterone	—	299
21	Emetine	—	298
22	Simvastatin	—	1,000
23	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
24	Miconazole	—	298
25	Nocodazole Nocodazole is	—	215
26	Podophyllotoxin	—	14
27	Ritonavir	—	298
28	egcg	—	300
29	2-Methoxyestradiol	—	300
30	Methotrexate	—	289
31	Anisomycin	—	247
32	Azathioprine	—	300
33	Bromocriptine	—	299
34	Calcimycin	—	216
35	cycloheximide	—	300
36	Danazol	—	298
37	Demecolcine	—	246
38	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
39	Digoxin	—	299
40	Equilin	—	216
41	Levonorgestrel	—	292
42	Lovastatin	—	300
43	Nandrolone C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less	—	300
44	Niclosamide	—	299
45	Norgestrel	—	300
46	Nortriptyline	—	28
47	streptonigrin	—	299
48	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
49	Tubercidin	—	300
50	tyrphostin 9	—	2

About the Abacavir ADME Pathway

The Abacavir ADME pathway is catalogued in Reactome (ID: R-HSA-2161522) and involves 4 genes. In the BiohacksAI corpus, 176 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCB1, ABCG2, SLC22A1, SLC22A3.