Downregulation of SMAD2/3:SMAD4 transcriptional activity

Q: What compounds affect the Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway?

102 compounds in the BiohacksAI corpus have documented interactions with genes in the Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway (Reactome ID: R-HSA-2173795). These compounds target 9 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-21737959 genes102 compounds

The Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway (Reactome ID: R-HSA-2173795) involves 9 genes and is affected by 102 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

HDAC1 MAPK1 MAPK3 NCOR1 NCOR2 PARP1 SMAD2 SMAD3 STAT1

Compounds Affecting Downregulation of SMAD2/3:SMAD4 transcriptional activity

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Daunorubicin	—	298
3	alsterpaullone	—	12
4	kenpaullone	—	8
5	Loratadine	—	296
6	Podophyllotoxin	—	14
7	egcg	—	300
8	Celecoxib	—	295
9	Nocodazole Nocodazole is	—	215
10	trequinsin hydrochloride	—	1
11	Vorinostat	—	299
12	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
13	Calcimycin	—	216
14	cycloheximide	—	300
15	Azacitidine	—	298
16	Azacitidine	—	300
17	Disulfiram	—	297
18	Nisoldipine	—	297
19	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
20	Kaempferols	—	300
21	Quercetin	—	300
22	Colchicine	—	300
23	Dactinomycin	—	297
24	Danazol	—	298
25	Dasatinib	—	299
26	Dinitrochlorobenzene	—	300
27	Ethidium	—	300
28	Flutamide	—	298
29	Oxyphenbutazone	—	300
30	vinblastine sulfate	—	81
31	Vincristine	—	299
32	chrysin	—	300
33	Fluoxetine	—	1,000
34	Methylene Blue	—	200
35	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
36	Astemizole Antihistamine drug now withdrawn from	—	280
37	Ciclopirox	—	88
38	Cladribine	—	297
39	Domperidone	—	299
40	Emetine	—	298
41	Equilin	—	216
42	Ethinyl Estradiol	—	300
43	Ezetimibe	—	296
44	Hexachlorophene	—	300
45	Idazoxan	—	300
46	Lynestrenol	—	299
47	Masoprocol	—	300
48	o-Phthalaldehyde	—	300
49	Perphenazine	—	297
50	pivampicillin	—	275

About the Downregulation of SMAD2/3:SMAD4 transcriptional activity Pathway

The Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway is catalogued in Reactome (ID: R-HSA-2173795) and involves 9 genes. In the BiohacksAI corpus, 102 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include HDAC1, MAPK1, MAPK3, NCOR1, NCOR2.