What compounds affect the DAP12 signaling pathway?

210 compounds in the BiohacksAI corpus have documented interactions with genes in the DAP12 signaling pathway (Reactome ID: R-HSA-2424491). These compounds target 9 genes within this pathway.

What genes are in the DAP12 signaling pathway?

The DAP12 signaling pathway involves 9 genes. Key genes include: BTK, FYN, GRB2, LAT, LCK, PIK3CB, PIK3R1, PIK3R2, SYK.

DAP12 signaling

REACTOME PATHWAY

Reactome: R-HSA-24244919 genes210 compounds

The DAP12 signaling pathway (Reactome ID: R-HSA-2424491) involves 9 genes and is affected by 210 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

BTK FYN GRB2 LAT LCK PIK3CB PIK3R1 PIK3R2 SYK

Compounds Affecting DAP12 signaling

#	Compound	Targets Hit	Studies
1	Dasatinib	—	299
2	Crizotinib	—	298
3	tyrphostin ag 1478	—	4
4	ly294002	—	11
5	pictilisib	—	25
6	alpelisib	—	227
7	Sorafenib	—	300
8	kenpaullone	—	8
9	Sirolimus	—	300
10	sp600125	—	117
11	piceatannol	—	300
12	torin 1	—	10
13	Axitinib	—	298
14	Afatinib	—	297
15	Quercetin	—	300
16	Acetic Acid Product of	—	300
17	Swainsonine	—	300
18	Wortmannin	—	300
19	Ouabain	—	300
20	Atorvastatin	—	1,000
21	Simvastatin	—	1,000
22	Methotrexate	—	289
23	Chlorhexidine	—	299
24	Clofarabine	—	298
25	Colchicine	—	300
26	cycloheximide	—	300
27	deguelin [Supplementary Concept]	—	151
28	Digoxin	—	299
29	Disulfiram	—	297
30	Emetine	—	298
31	Ezetimibe	—	296
32	Lovastatin	—	300
33	Medroxyprogesterone Acetate	—	299
34	Melphalan	—	300
35	Mometasone Furoate	—	292
36	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
37	Niclosamide	—	299
38	Podophyllotoxin	—	14
39	Thapsigargin	—	300
40	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
41	Trifluridine	—	295
42	fisetin	—	78
43	ag490	—	14
44	Azathioprine	—	300
45	Bortezomib	—	300
46	Maprotiline	—	299
47	Nocodazole Nocodazole is	—	215
48	N-pyridazin-3-yl-4-(3-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzylidene)piperidine-1-carboxamide [Supplementary Concept]	—	8
49	Tripterygium	—	300
50	Vincristine	—	299

About the DAP12 signaling Pathway

The DAP12 signaling pathway is catalogued in Reactome (ID: R-HSA-2424491) and involves 9 genes. In the BiohacksAI corpus, 210 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BTK, FYN, GRB2, LAT, LCK.