Formation of Senescence-Associated Heterochromatin Foci (SAHF)

Q: What compounds affect the Formation of Senescence-Associated Heterochromatin Foci (SAHF) pathway?

151 compounds in the BiohacksAI corpus have documented interactions with genes in the Formation of Senescence-Associated Heterochromatin Foci (SAHF) pathway (Reactome ID: R-HSA-2559584). These compounds target 1 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-25595841 genes151 compounds

The Formation of Senescence-Associated Heterochromatin Foci (SAHF) pathway (Reactome ID: R-HSA-2559584) involves 1 genes and is affected by 151 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

TP53

Compounds Affecting Formation of Senescence-Associated Heterochromatin Foci (SAHF)

#	Compound	Targets Hit	Studies
1	Ethidium	—	300
2	Ethinyl Estradiol	—	300
3	Hexachlorophene	—	300
4	Azacitidine	—	298
5	Azacitidine	—	300
6	Methylene Blue	—	200
7	Bortezomib	—	300
8	Rotenone	—	300
9	Azathioprine	—	300
10	Cladribine	—	297
11	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
12	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
13	Cytarabine	—	297
14	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
15	Melphalan	—	300
16	Niclosamide	—	299
17	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
18	Methotrexate	—	289
19	Dactinomycin	—	297
20	Daunorubicin	—	298
21	Disulfiram	—	297
22	Glutaral	—	42
23	Vitamin K 3	—	300
24	Trifluridine	—	295
25	Quercetin	—	300
26	Axitinib	—	298
27	ninhydrin	—	300
28	o-Phthalaldehyde	—	300
29	Razoxane	—	154
30	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
31	plumbagin [Supplementary Concept]	—	300
32	Camptothecin	—	300
33	Reserpine	—	297
34	Genistein	—	300
35	Resveratrol	—	298
36	Ciclopirox	—	88
37	Clofarabine	—	298
38	cycloheximide	—	300
39	daph	—	2
40	Dinitrochlorobenzene	—	300
41	Estramustine	—	300
42	3-(1-(3-hydroxy-4-methoxyphenyl)methylidene)-6-methylchroman-4-one [Supplementary Concept]	—	1
43	Loratadine	—	296
44	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
45	Riluzole	—	298
46	Thioinosine Sulfhydryl analog of INOSINE that inhibits nucleoside transport across erythrocyte plasma membranes, and has immunosuppressive properties. It has been used similarly to MERCAPTOPURINE in	—	242
47	Trabectedin	—	297
48	Vorinostat	—	299
49	Clotrimazole	—	296
50	Demeclocycline	—	5

About the Formation of Senescence-Associated Heterochromatin Foci (SAHF) Pathway

The Formation of Senescence-Associated Heterochromatin Foci (SAHF) pathway is catalogued in Reactome (ID: R-HSA-2559584) and involves 1 genes. In the BiohacksAI corpus, 151 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include TP53.