SUMOylation of DNA damage response and repair proteins

Q: What compounds affect the SUMOylation of DNA damage response and repair proteins pathway?

88 compounds in the BiohacksAI corpus have documented interactions with genes in the SUMOylation of DNA damage response and repair proteins pathway (Reactome ID: R-HSA-3108214). These compounds target 7 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-31082147 genes88 compounds

The SUMOylation of DNA damage response and repair proteins pathway (Reactome ID: R-HSA-3108214) involves 7 genes and is affected by 88 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

BLM BRCA1 HDAC7 PARP1 RAD52 SUMO1 WRN

Compounds Affecting SUMOylation of DNA damage response and repair proteins

#	Compound	Targets Hit	Studies
1	Daunorubicin	—	298
2	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
3	Chlorhexidine	—	299
4	Demecolcine	—	246
5	Hexachlorophene	—	300
6	Nocodazole Nocodazole is	—	215
7	Podophyllotoxin	—	14
8	Aurintricarboxylic Acid	—	184
9	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
10	Methylene Blue	—	200
11	Levodopa	—	297
12	Camptothecin	—	300
13	Oxytetracycline	—	300
14	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
15	Resveratrol	—	298
16	Methotrexate	—	289
17	Astemizole Antihistamine drug now withdrawn from	—	280
18	Azacitidine	—	298
19	Azacitidine	—	300
20	Calcimycin	—	216
21	calycosin	—	300
22	Ciclopirox	—	88
23	Colchicine	—	300
24	colchine	—	2
25	cycloheximide	—	300
26	Cytarabine	—	297
27	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
28	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
29	dihydrorotenone	—	13
30	Fluspirilene	—	74
31	gedunin	—	54
32	lidoflazine	—	278
33	Melphalan	—	300
34	Niclosamide	—	299
35	paxilline	—	42
36	rafoxanide	—	172
37	Semustine 4-Methyl derivative of LOMUSTINE; (CCNU).	—	97
38	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
39	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
40	Trifluridine	—	295
41	Tubercidin	—	300
42	vinblastine sulfate	—	81
43	Quercetin	—	300
44	Estramustine	—	300
45	Idarubicin	—	299
46	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
47	DEAD-box RNA Helicases	—	169
48	Thioctic Acid	—	298
49	Rosmarinic Acid	—	300
50	Dihydroxyphenylalanine	—	300

About the SUMOylation of DNA damage response and repair proteins Pathway

The SUMOylation of DNA damage response and repair proteins pathway is catalogued in Reactome (ID: R-HSA-3108214) and involves 7 genes. In the BiohacksAI corpus, 88 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BLM, BRCA1, HDAC7, PARP1, RAD52.