What genes are in the Dopamine clearance from the synaptic cleft pathway?

The Dopamine clearance from the synaptic cleft pathway involves 2 genes. Key genes include: MAOA, SLC6A3.

Dopamine clearance from the synaptic cleft

Q: What compounds affect the Dopamine clearance from the synaptic cleft pathway?

98 compounds in the BiohacksAI corpus have documented interactions with genes in the Dopamine clearance from the synaptic cleft pathway (Reactome ID: R-HSA-379401). These compounds target 2 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-3794012 genes98 compounds

The Dopamine clearance from the synaptic cleft pathway (Reactome ID: R-HSA-379401) involves 2 genes and is affected by 98 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

MAOA SLC6A3

Compounds Affecting Dopamine clearance from the synaptic cleft

#	Compound	Targets Hit	Studies
1	Aripiprazole	—	298
2	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
3	pentamidine	—	299
4	Phenelzine	—	297
5	Sorafenib	—	300
6	Duloxetine Hydrochloride	—	993
7	Fluoxetine	—	1,000
8	Modafinil	—	297
9	Sertraline	—	1,000
10	Venlafaxine Hydrochloride	—	1,000
11	Digoxin	—	299
12	Ouabain	—	300
13	Ticagrelor	—	299
14	Amlodipine	—	1,000
15	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
16	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
17	Cabergoline	—	299
18	Ethinyl Estradiol	—	300
19	Ibogaine	—	300
20	streptonigrin	—	299
21	Escitalopram S-enantiomer of CITALOPRAM. Belongs to	—	995
22	Simvastatin	—	1,000
23	Amoxapine	—	259
24	Antazoline	—	229
25	Astemizole Antihistamine drug now withdrawn from	—	280
26	Axitinib	—	298
27	Benzydamine	—	298
28	Calcitriol	—	300
29	Canagliflozin	—	295
30	Carvedilol	—	296
31	Caspofungin	—	299
32	Celecoxib	—	295
33	Cetirizine	—	296
34	Chlorhexidine	—	299
35	Chlorpheniramine	—	298
36	cinacalcet	—	298
37	Cinnarizine	—	299
38	Crizotinib	—	298
39	Cyclizine	—	251
40	Dequalinium	—	136
41	Digitoxin	—	300
42	Domperidone	—	299
43	Estrone	—	300
44	Flunarizine Flunarizine is	—	299
45	Fluspirilene	—	74
46	Fluvoxamine	—	297
47	Hexachlorophene	—	300
48	Indomethacin	—	297
49	Labetalol	—	295
50	Leflunomide	—	297

About the Dopamine clearance from the synaptic cleft Pathway

The Dopamine clearance from the synaptic cleft pathway is catalogued in Reactome (ID: R-HSA-379401) and involves 2 genes. In the BiohacksAI corpus, 98 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include MAOA, SLC6A3.