What genes are in the Serotonin clearance from the synaptic cleft pathway?

The Serotonin clearance from the synaptic cleft pathway involves 3 genes. Key genes include: ALDH2, MAOA, SLC6A4.

Serotonin clearance from the synaptic cleft

Q: What compounds affect the Serotonin clearance from the synaptic cleft pathway?

100 compounds in the BiohacksAI corpus have documented interactions with genes in the Serotonin clearance from the synaptic cleft pathway (Reactome ID: R-HSA-380615). These compounds target 3 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-3806153 genes100 compounds

The Serotonin clearance from the synaptic cleft pathway (Reactome ID: R-HSA-380615) involves 3 genes and is affected by 100 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ALDH2 MAOA SLC6A4

Compounds Affecting Serotonin clearance from the synaptic cleft

#	Compound	Targets Hit	Studies
1	Aripiprazole	—	298
2	pentamidine	—	299
3	Phenelzine	—	297
4	Fluoxetine	—	1,000
5	Venlafaxine Hydrochloride	—	1,000
6	Sertraline	—	1,000
7	Vortioxetine	—	294
8	Duloxetine Hydrochloride	—	993
9	Escitalopram S-enantiomer of CITALOPRAM. Belongs to	—	995
10	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
11	Fluvoxamine	—	297
12	Quipazine	—	300
13	Amoxapine	—	259
14	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
15	Ethinyl Estradiol	—	300
16	Meperidine	—	297
17	Metergoline	—	144
18	Nortriptyline	—	295
19	Promethazine	—	296
20	Mianserin	—	299
21	vinpocetine	—	299
22	Aprindine	—	300
23	Astemizole Antihistamine drug now withdrawn from	—	280
24	Benzydamine	—	298
25	Carvedilol	—	296
26	Celecoxib	—	295
27	Cetirizine	—	296
28	Chlorhexidine	—	299
29	Chlorpheniramine	—	298
30	cinacalcet	—	298
31	Cinnarizine	—	299
32	Clotrimazole	—	296
33	Crizotinib	—	298
34	Cyproheptadine	—	299
35	Dequalinium	—	136
36	Desogestrel	—	299
37	Dextromethorphan Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of	—	296
38	dilazep	—	300
39	Econazole	—	299
40	Estrone	—	300
41	Fenoterol	—	300
42	Flunarizine Flunarizine is	—	299
43	Fluspirilene	—	74
44	Gestrinone	—	221
45	hydroxyfasudil [Supplementary Concept]	—	11
46	Idarubicin	—	299
47	Levorphanol	—	297
48	lidoflazine	—	278
49	Loxapine	—	225
50	Mestranol	—	300

About the Serotonin clearance from the synaptic cleft Pathway

The Serotonin clearance from the synaptic cleft pathway is catalogued in Reactome (ID: R-HSA-380615) and involves 3 genes. In the BiohacksAI corpus, 100 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ALDH2, MAOA, SLC6A4.