Association of TriC/CCT with target proteins during biosynthesis

Q: What compounds affect the Association of TriC/CCT with target proteins during biosynthesis pathway?

162 compounds in the BiohacksAI corpus have documented interactions with genes in the Association of TriC/CCT with target proteins during biosynthesis pathway (Reactome ID: R-HSA-390471). These compounds target 7 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-3904717 genes162 compounds

The Association of TriC/CCT with target proteins during biosynthesis pathway (Reactome ID: R-HSA-390471) involves 7 genes and is affected by 162 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CCNE2 CCT2 GBA1 HDAC3 SPHK1 STAT3 TP53

Compounds Affecting Association of TriC/CCT with target proteins during biosynthesis

#	Compound	Targets Hit	Studies
1	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
2	Methylene Blue	—	200
3	Bortezomib	—	300
4	Niclosamide	—	299
5	Daunorubicin	—	298
6	Quercetin	—	300
7	Camptothecin	—	300
8	Genistein	—	300
9	Vorinostat	—	299
10	Adenosine Triphosphate	—	300
11	Chlorhexidine	—	299
12	Celecoxib	—	295
13	Ethidium	—	300
14	Ethinyl Estradiol	—	300
15	Hexachlorophene	—	300
16	Azacitidine	—	298
17	Azacitidine	—	300
18	Rotenone	—	300
19	Azathioprine	—	300
20	Cladribine	—	297
21	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
22	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
23	Cytarabine	—	297
24	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
25	Melphalan	—	300
26	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
27	Methotrexate	—	289
28	Dactinomycin	—	297
29	Disulfiram	—	297
30	Glutaral	—	42
31	Vitamin K 3	—	300
32	Trifluridine	—	295
33	Axitinib	—	298
34	ninhydrin	—	300
35	o-Phthalaldehyde	—	300
36	Razoxane	—	154
37	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
38	plumbagin [Supplementary Concept]	—	300
39	Reserpine	—	297
40	Resveratrol	—	298
41	Ciclopirox	—	88
42	Clofarabine	—	298
43	cycloheximide	—	300
44	daph	—	2
45	Dinitrochlorobenzene	—	300
46	Estramustine	—	300
47	3-(1-(3-hydroxy-4-methoxyphenyl)methylidene)-6-methylchroman-4-one [Supplementary Concept]	—	1
48	Loratadine	—	296
49	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
50	Riluzole	—	298

About the Association of TriC/CCT with target proteins during biosynthesis Pathway

The Association of TriC/CCT with target proteins during biosynthesis pathway is catalogued in Reactome (ID: R-HSA-390471) and involves 7 genes. In the BiohacksAI corpus, 162 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CCNE2, CCT2, GBA1, HDAC3, SPHK1.