What compounds affect the G alpha (q) signalling events pathway?

488 compounds in the BiohacksAI corpus have documented interactions with genes in the G alpha (q) signalling events pathway (Reactome ID: R-HSA-416476). These compounds target 78 genes within this pathway.

What genes are in the G alpha (q) signalling events pathway?

The G alpha (q) signalling events pathway involves 78 genes. Key genes include: ADRA1A, ADRA1B, ADRA1D, AGTR1, APP, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BTK.

G alpha (q) signalling events

REACTOME PATHWAY

Reactome: R-HSA-41647678 genes488 compounds

The G alpha (q) signalling events pathway (Reactome ID: R-HSA-416476) involves 78 genes and is affected by 488 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRA1A ADRA1B ADRA1D AGTR1 APP AVPR1A AVPR1B BDKRB1 BDKRB2 BTK CASR CCKBR CHRM1 CHRM3 CHRM5 CREB1 CYSLTR1 CYSLTR2 EDNRA EDNRB EGFR F2RL1 FFAR1 FFAR2 FFAR3 FFAR4 FPR2 GHSR GNA15 GNRHR+48 more

Compounds Affecting G alpha (q) signalling events

#	Compound	Targets Hit	Studies
1	Aripiprazole	—	298
2	Astemizole Antihistamine drug now withdrawn from	—	280
3	Fluspirilene	—	74
4	Fluoxetine	—	1,000
5	Carvedilol	—	296
6	Quetiapine Fumarate	—	994
7	Amoxapine	—	259
8	Cyproheptadine	—	299
9	Loxapine	—	225
10	Mianserin	—	299
11	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
12	Metergoline	—	144
13	Calcimycin	—	216
14	Chlorhexidine	—	299
15	Maprotiline	—	299
16	Perphenazine	—	297
17	Thioridazine	—	35
18	Nortriptyline	—	295
19	Trazodone	—	297
20	Promethazine	—	296
21	oxatomide [Supplementary Concept] structure;	—	128
22	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
23	Hydroxyzine	—	298
24	Oxymetazoline	—	298
25	Dihydroergotamine	—	299
26	Pergolide	—	299
27	candesartan cilexetil [Supplementary Concept]	—	300
28	Loratadine	—	296
29	Promethazine	—	121
30	Riboflavin Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables.	—	297
31	protriptyline	—	296
32	Daunorubicin	—	298
33	Hexachlorophene	—	300
34	Amlodipine	—	1,000
35	Disulfiram	—	297
36	Yohimbine	—	299
37	Buspirone	—	299
38	Dihydroergotamine	—	9
39	Duloxetine Hydrochloride	—	993
40	Losartan	—	1,000
41	Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is	—	298
42	Methylergonovine	—	193
43	Methysergide	—	300
44	Ritonavir	—	298
45	Sorafenib	—	300
46	Methylene Blue	—	200
47	Adenosine Triphosphate	—	300
48	Hyoscyamine	—	296
49	Arecoline	—	299
50	Clotrimazole	—	296

About the G alpha (q) signalling events Pathway

The G alpha (q) signalling events pathway is catalogued in Reactome (ID: R-HSA-416476) and involves 78 genes. In the BiohacksAI corpus, 488 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRA1A, ADRA1B, ADRA1D, AGTR1, APP.