Activation of the AP-1 family of transcription factors

Q: What compounds affect the Activation of the AP-1 family of transcription factors pathway?

106 compounds in the BiohacksAI corpus have documented interactions with genes in the Activation of the AP-1 family of transcription factors pathway (Reactome ID: R-HSA-450341). These compounds target 9 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-4503419 genes106 compounds

The Activation of the AP-1 family of transcription factors pathway (Reactome ID: R-HSA-450341) involves 9 genes and is affected by 106 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

FOS JUN MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9

Compounds Affecting Activation of the AP-1 family of transcription factors

#	Compound	Targets Hit	Studies
1	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
2	Sorafenib	—	300
3	Anisomycin	—	247
4	sp600125	—	117
5	withaferin	—	300
6	Afatinib	—	297
7	fisetin	—	78
8	pictilisib	—	25
9	Diphenhydramine	—	14
10	egcg	—	300
11	Lithocholic Acid	—	300
12	Clotrimazole	—	296
13	Masoprocol	—	300
14	plumbagin [Supplementary Concept]	—	300
15	pd98059	—	7
16	tyrphostin ag 1478	—	4
17	alsterpaullone	—	12
18	kenpaullone	—	8
19	trametinib	—	296
20	Dasatinib	—	299
21	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
22	Quercetin	—	300
23	Axitinib	—	298
24	cardamonin	—	180
25	Hesperidin	—	300
26	Colchicine	—	300
27	DEAD-box RNA Helicases	—	169
28	Thioctic Acid	—	298
29	Disulfiram	—	297
30	glaucarubinone	—	10
31	Thioctic Acid	—	300
32	vinblastine sulfate	—	81
33	Methylene Blue	—	200
34	Amoxapine	—	259
35	Cinnarizine	—	299
36	Clofibrate	—	299
37	Ethoxyquin Antioxidant; also	—	180
38	Fenofibrate	—	297
39	Lovastatin	—	300
40	Lynestrenol	—	299
41	Medroxyprogesterone Acetate	—	299
42	Vitamin K 3	—	300
43	Mestranol	—	300
44	Phenoxybenzamine	—	21
45	Podophyllotoxin	—	14
46	Promethazine	—	121
47	triflupromazine hydrochloride	—	12
48	Vincamine	—	300
49	Azithromycin	—	1,000
50	Budesonide	—	1,000

About the Activation of the AP-1 family of transcription factors Pathway

The Activation of the AP-1 family of transcription factors pathway is catalogued in Reactome (ID: R-HSA-450341) and involves 9 genes. In the BiohacksAI corpus, 106 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include FOS, JUN, MAPK1, MAPK10, MAPK11.