What compounds affect the Phase 3 - rapid repolarisation pathway?

155 compounds in the BiohacksAI corpus have documented interactions with genes in the Phase 3 - rapid repolarisation pathway (Reactome ID: R-HSA-5576890). These compounds target 4 genes within this pathway.

What genes are in the Phase 3 - rapid repolarisation pathway?

The Phase 3 - rapid repolarisation pathway involves 4 genes. Key genes include: KCNA5, KCNE1, KCNH2, KCNQ1.

Phase 3 - rapid repolarisation

REACTOME PATHWAY

Reactome: R-HSA-55768904 genes155 compounds

The Phase 3 - rapid repolarisation pathway (Reactome ID: R-HSA-5576890) involves 4 genes and is affected by 155 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

KCNA5 KCNE1 KCNH2 KCNQ1

Compounds Affecting Phase 3 - rapid repolarisation

#	Compound	Targets Hit	Studies
1	Duloxetine Hydrochloride	—	993
2	Quinidine	—	298
3	vinpocetine	—	299
4	Clotrimazole	—	296
5	Flecainide	—	297
6	Thioridazine	—	35
7	Oleic Acid	—	112
8	17 alpha-Hydroxyprogesterone Caproate Hydroxyprogesterone derivative that acts as	—	287
9	Nisoldipine	—	297
10	Calcimycin	—	216
11	Nortriptyline	—	28
12	dihydrorotenone	—	13
13	Astemizole Antihistamine drug now withdrawn from	—	280
14	dofetilide	—	298
15	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
16	Aripiprazole	—	298
17	Domperidone	—	299
18	Loratadine	—	296
19	Fluoxetine	—	1,000
20	Reserpine	—	297
21	lidoflazine	—	278
22	clofilium tosylate	—	4
23	Fluspirilene	—	74
24	Vincamine	—	300
25	Amoxapine	—	259
26	Fenofibrate	—	297
27	Lumefantrine	—	299
28	Phenoxybenzamine	—	21
29	Cinnarizine	—	299
30	Metergoline	—	144
31	Nitrendipine	—	299
32	Ondansetron	—	299
33	Perphenazine	—	297
34	Rimonabant	—	300
35	Celecoxib	—	295
36	Dibucaine	—	299
37	dilazep	—	300
38	Flunarizine Flunarizine is	—	299
39	Hydroxyzine	—	298
40	Lovastatin	—	300
41	Loxapine	—	30
42	Maprotiline	—	299
43	Vitamin K 3	—	300
44	Nebivolol	—	297
45	Nicergoline	—	300
46	Nylidrin	—	90
47	oxatomide [Supplementary Concept] structure;	—	128
48	Phentolamine	—	300
49	pirenperone	—	22
50	Promazine	—	40

About the Phase 3 - rapid repolarisation Pathway

The Phase 3 - rapid repolarisation pathway is catalogued in Reactome (ID: R-HSA-5576890) and involves 4 genes. In the BiohacksAI corpus, 155 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include KCNA5, KCNE1, KCNH2, KCNQ1.