What compounds affect the Defective CYP19A1 causes AEXS pathway?

102 compounds in the BiohacksAI corpus have documented interactions with genes in the Defective CYP19A1 causes AEXS pathway (Reactome ID: R-HSA-5579030). These compounds target 1 genes within this pathway.

What genes are in the Defective CYP19A1 causes AEXS pathway?

The Defective CYP19A1 causes AEXS pathway involves 1 genes. Key genes include: CYP19A1.

Defective CYP19A1 causes AEXS

REACTOME PATHWAY

Reactome: R-HSA-55790301 genes102 compounds

The Defective CYP19A1 causes AEXS pathway (Reactome ID: R-HSA-5579030) involves 1 genes and is affected by 102 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CYP19A1

Compounds Affecting Defective CYP19A1 causes AEXS

#	Compound	Targets Hit	Studies
1	Letrozole	—	298
2	Fadrozole	—	300
3	Anastrozole	—	298
4	Kaempferols	—	300
5	chrysin	—	300
6	Androstenedione	—	300
7	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
8	Clotrimazole	—	296
9	Methylene Blue	—	200
10	Testosterone	—	299
11	Bortezomib	—	300
12	cycloheximide	—	300
13	Ethidium	—	300
14	Fulvestrant	—	295
15	Lovastatin	—	300
16	Miconazole	—	298
17	Reserpine	—	297
18	Spironolactone	—	298
19	Vitamin	—	295
20	Dactinomycin	—	297
21	Dihydrotestosterone	—	300
22	Disulfiram	—	297
23	Hexachlorophene	—	300
24	mg624	—	3
25	Ouabain	—	300
26	Rotenone	—	300
27	stx64	—	2
28	Acetaldehyde	—	300
29	Amoxapine	—	259
30	Astemizole Antihistamine drug now withdrawn from	—	280
31	Azacitidine	—	298
32	Azacitidine	—	300
33	Celecoxib	—	295
34	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
35	Chlorhexidine	—	299
36	Daunorubicin	—	298
37	Digoxin	—	299
38	Dinitrochlorobenzene	—	300
39	Emetine	—	298
40	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
41	Flutamide	—	298
42	Nisoldipine	—	297
43	Nitrofurantoin	—	297
44	ns398	—	116
45	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
46	Toxaphene	—	299
47	Trabectedin	—	297
48	Troglitazone	—	299
49	Atorvastatin	—	1,000
50	Kaempferols	—	300

About the Defective CYP19A1 causes AEXS Pathway

The Defective CYP19A1 causes AEXS pathway is catalogued in Reactome (ID: R-HSA-5579030) and involves 1 genes. In the BiohacksAI corpus, 102 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CYP19A1.