What genes are in the TP53 Regulates Transcription of Cell Death Genes pathway?

The TP53 Regulates Transcription of Cell Death Genes pathway involves 6 genes. Key genes include: ATM, BIRC5, CASP1, CASP2, CREBBP, TP53.

TP53 Regulates Transcription of Cell Death Genes

Q: What compounds affect the TP53 Regulates Transcription of Cell Death Genes pathway?

162 compounds in the BiohacksAI corpus have documented interactions with genes in the TP53 Regulates Transcription of Cell Death Genes pathway (Reactome ID: R-HSA-5633008). These compounds target 6 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-56330086 genes162 compounds

The TP53 Regulates Transcription of Cell Death Genes pathway (Reactome ID: R-HSA-5633008) involves 6 genes and is affected by 162 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ATM BIRC5 CASP1 CASP2 CREBBP TP53

Compounds Affecting TP53 Regulates Transcription of Cell Death Genes

#	Compound	Targets Hit	Studies
1	Ethinyl Estradiol	—	300
2	Hexachlorophene	—	300
3	Methylene Blue	—	200
4	Disulfiram	—	297
5	Vitamin K 3	—	300
6	Thioridazine	—	35
7	Nocodazole Nocodazole is	—	215
8	Colchicine	—	300
9	Ethidium	—	300
10	Azacitidine	—	298
11	Azacitidine	—	300
12	Bortezomib	—	300
13	Rotenone	—	300
14	Azathioprine	—	300
15	Cladribine	—	297
16	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
17	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
18	Cytarabine	—	297
19	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
20	Melphalan	—	300
21	Niclosamide	—	299
22	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
23	Methotrexate	—	289
24	Dactinomycin	—	297
25	Daunorubicin	—	298
26	Glutaral	—	42
27	Trifluridine	—	295
28	Quercetin	—	300
29	Axitinib	—	298
30	ninhydrin	—	300
31	o-Phthalaldehyde	—	300
32	Razoxane	—	154
33	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
34	plumbagin [Supplementary Concept]	—	300
35	Camptothecin	—	300
36	Reserpine	—	297
37	Genistein	—	300
38	Resveratrol	—	298
39	Ciclopirox	—	88
40	Clofarabine	—	298
41	cycloheximide	—	300
42	daph	—	2
43	Dinitrochlorobenzene	—	300
44	Estramustine	—	300
45	3-(1-(3-hydroxy-4-methoxyphenyl)methylidene)-6-methylchroman-4-one [Supplementary Concept]	—	1
46	Loratadine	—	296
47	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
48	Riluzole	—	298
49	Thioinosine Sulfhydryl analog of INOSINE that inhibits nucleoside transport across erythrocyte plasma membranes, and has immunosuppressive properties. It has been used similarly to MERCAPTOPURINE in	—	242
50	Trabectedin	—	297

About the TP53 Regulates Transcription of Cell Death Genes Pathway

The TP53 Regulates Transcription of Cell Death Genes pathway is catalogued in Reactome (ID: R-HSA-5633008) and involves 6 genes. In the BiohacksAI corpus, 162 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ATM, BIRC5, CASP1, CASP2, CREBBP.