What compounds affect the Ovarian tumor domain proteases pathway?

346 compounds in the BiohacksAI corpus have documented interactions with genes in the Ovarian tumor domain proteases pathway (Reactome ID: R-HSA-5689896). These compounds target 8 genes within this pathway.

What genes are in the Ovarian tumor domain proteases pathway?

The Ovarian tumor domain proteases pathway involves 8 genes. Key genes include: CDK1, ESR1, NOD1, NOD2, OTUD3, RIPK2, TP53, VCP.

Ovarian tumor domain proteases

REACTOME PATHWAY

Reactome: R-HSA-56898968 genes346 compounds

The Ovarian tumor domain proteases pathway (Reactome ID: R-HSA-5689896) involves 8 genes and is affected by 346 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CDK1 ESR1 NOD1 NOD2 OTUD3 RIPK2 TP53 VCP

Compounds Affecting Ovarian tumor domain proteases

#	Compound	Targets Hit	Studies
1	cycloheximide	—	300
2	Hexachlorophene	—	300
3	Digoxin	—	299
4	Quercetin	—	300
5	Clotrimazole	—	296
6	Digitoxin	—	300
7	Rotenone	—	300
8	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
9	chrysin	—	300
10	Axitinib	—	298
11	Ouabain	—	300
12	Fenofibrate	—	297
13	Dasatinib	—	299
14	Disulfiram	—	297
15	Cinnarizine	—	299
16	Clofibrate	—	299
17	Demeclocycline	—	5
18	Camptothecin	—	300
19	Oxyphenbutazone	—	300
20	Resveratrol	—	298
21	Ethinyl Estradiol	—	300
22	Genistein	—	300
23	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
24	Methyltestosterone	—	300
25	Dactinomycin	—	297
26	Ethidium	—	300
27	Ethynodiol Diacetate	—	300
28	Reserpine	—	297
29	Colchicine	—	300
30	Pueraria	—	300
31	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
32	Progesterone	—	299
33	Bortezomib	—	300
34	Trabectedin	—	297
35	Niclosamide	—	299
36	Triiodothyronine	—	300
37	vinblastine sulfate	—	81
38	Loratadine	—	296
39	Melphalan	—	300
40	Adapalene	—	296
41	Chlorhexidine	—	299
42	Ciclopirox	—	88
43	Daunorubicin	—	298
44	Estramustine	—	300
45	Ethylestrenol	—	70
46	Nitrofurantoin	—	297
47	Emetine	—	298
48	Vitamin K 3	—	300
49	o-Phthalaldehyde	—	300
50	Spironolactone	—	298

About the Ovarian tumor domain proteases Pathway

The Ovarian tumor domain proteases pathway is catalogued in Reactome (ID: R-HSA-5689896) and involves 8 genes. In the BiohacksAI corpus, 346 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDK1, ESR1, NOD1, NOD2, OTUD3.