TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain

Q: What compounds affect the TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain pathway?

152 compounds in the BiohacksAI corpus have documented interactions with genes in the TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain pathway (Reactome ID: R-HSA-6803205). These compounds target 2 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-68032052 genes152 compounds

The TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain pathway (Reactome ID: R-HSA-6803205) involves 2 genes and is affected by 152 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

BIRC5 TP53

Compounds Affecting TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain

#	Compound	Targets Hit	Studies
1	Vitamin K 3	—	300
2	Ethidium	—	300
3	Ethinyl Estradiol	—	300
4	Hexachlorophene	—	300
5	Azacitidine	—	298
6	Azacitidine	—	300
7	Methylene Blue	—	200
8	Bortezomib	—	300
9	Rotenone	—	300
10	Azathioprine	—	300
11	Cladribine	—	297
12	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
13	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
14	Cytarabine	—	297
15	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
16	Melphalan	—	300
17	Niclosamide	—	299
18	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
19	Methotrexate	—	289
20	Dactinomycin	—	297
21	Daunorubicin	—	298
22	Disulfiram	—	297
23	Glutaral	—	42
24	Trifluridine	—	295
25	Quercetin	—	300
26	Axitinib	—	298
27	ninhydrin	—	300
28	o-Phthalaldehyde	—	300
29	Razoxane	—	154
30	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
31	plumbagin [Supplementary Concept]	—	300
32	Camptothecin	—	300
33	Reserpine	—	297
34	Genistein	—	300
35	Resveratrol	—	298
36	Ciclopirox	—	88
37	Clofarabine	—	298
38	cycloheximide	—	300
39	daph	—	2
40	Dinitrochlorobenzene	—	300
41	Estramustine	—	300
42	3-(1-(3-hydroxy-4-methoxyphenyl)methylidene)-6-methylchroman-4-one [Supplementary Concept]	—	1
43	Loratadine	—	296
44	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
45	Riluzole	—	298
46	Thioinosine Sulfhydryl analog of INOSINE that inhibits nucleoside transport across erythrocyte plasma membranes, and has immunosuppressive properties. It has been used similarly to MERCAPTOPURINE in	—	242
47	Trabectedin	—	297
48	Vorinostat	—	299
49	Clotrimazole	—	296
50	Demeclocycline	—	5

About the TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain Pathway

The TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain pathway is catalogued in Reactome (ID: R-HSA-6803205) and involves 2 genes. In the BiohacksAI corpus, 152 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BIRC5, TP53.