TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

Q: What compounds affect the TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain pathway?

154 compounds in the BiohacksAI corpus have documented interactions with genes in the TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain pathway (Reactome ID: R-HSA-6804115). These compounds target 4 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-68041154 genes154 compounds

The TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain pathway (Reactome ID: R-HSA-6804115) involves 4 genes and is affected by 154 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

NPM1 PLK2 PLK3 TP53

Compounds Affecting TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

#	Compound	Targets Hit	Studies
1	Wortmannin	—	300
2	Ethidium	—	300
3	Ethinyl Estradiol	—	300
4	Hexachlorophene	—	300
5	Azacitidine	—	298
6	Azacitidine	—	300
7	Methylene Blue	—	200
8	Bortezomib	—	300
9	Rotenone	—	300
10	Azathioprine	—	300
11	Cladribine	—	297
12	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
13	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
14	Cytarabine	—	297
15	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
16	Melphalan	—	300
17	Niclosamide	—	299
18	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
19	Methotrexate	—	289
20	Dactinomycin	—	297
21	Daunorubicin	—	298
22	Disulfiram	—	297
23	Glutaral	—	42
24	Vitamin K 3	—	300
25	Trifluridine	—	295
26	Quercetin	—	300
27	Axitinib	—	298
28	ninhydrin	—	300
29	o-Phthalaldehyde	—	300
30	Razoxane	—	154
31	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
32	plumbagin [Supplementary Concept]	—	300
33	Camptothecin	—	300
34	Reserpine	—	297
35	Genistein	—	300
36	Resveratrol	—	298
37	Ciclopirox	—	88
38	Clofarabine	—	298
39	cycloheximide	—	300
40	daph	—	2
41	Dinitrochlorobenzene	—	300
42	Estramustine	—	300
43	3-(1-(3-hydroxy-4-methoxyphenyl)methylidene)-6-methylchroman-4-one [Supplementary Concept]	—	1
44	Loratadine	—	296
45	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
46	Riluzole	—	298
47	Thioinosine Sulfhydryl analog of INOSINE that inhibits nucleoside transport across erythrocyte plasma membranes, and has immunosuppressive properties. It has been used similarly to MERCAPTOPURINE in	—	242
48	Trabectedin	—	297
49	Vorinostat	—	299
50	Clotrimazole	—	296

About the TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain Pathway

The TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain pathway is catalogued in Reactome (ID: R-HSA-6804115) and involves 4 genes. In the BiohacksAI corpus, 154 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include NPM1, PLK2, PLK3, TP53.