TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest

Q: What compounds affect the TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest pathway?

155 compounds in the BiohacksAI corpus have documented interactions with genes in the TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest pathway (Reactome ID: R-HSA-6804116). These compounds target 4 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-68041164 genes155 compounds

The TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest pathway (Reactome ID: R-HSA-6804116) involves 4 genes and is affected by 155 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CCNA1 CCNE2 CDK2 TP53

Compounds Affecting TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest

#	Compound	Targets Hit	Studies
1	sp600125	—	117
2	alsterpaullone	—	12
3	kenpaullone	—	8
4	Adenosine Triphosphate	—	300
5	Ethidium	—	300
6	Ethinyl Estradiol	—	300
7	Hexachlorophene	—	300
8	Azacitidine	—	298
9	Azacitidine	—	300
10	Methylene Blue	—	200
11	Bortezomib	—	300
12	Rotenone	—	300
13	Azathioprine	—	300
14	Cladribine	—	297
15	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
16	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
17	Cytarabine	—	297
18	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
19	Melphalan	—	300
20	Niclosamide	—	299
21	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
22	Methotrexate	—	289
23	Dactinomycin	—	297
24	Daunorubicin	—	298
25	Disulfiram	—	297
26	Glutaral	—	42
27	Vitamin K 3	—	300
28	Trifluridine	—	295
29	Quercetin	—	300
30	Axitinib	—	298
31	ninhydrin	—	300
32	o-Phthalaldehyde	—	300
33	Razoxane	—	154
34	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
35	plumbagin [Supplementary Concept]	—	300
36	Camptothecin	—	300
37	Reserpine	—	297
38	Genistein	—	300
39	Resveratrol	—	298
40	Ciclopirox	—	88
41	Clofarabine	—	298
42	cycloheximide	—	300
43	daph	—	2
44	Dinitrochlorobenzene	—	300
45	Estramustine	—	300
46	3-(1-(3-hydroxy-4-methoxyphenyl)methylidene)-6-methylchroman-4-one [Supplementary Concept]	—	1
47	Loratadine	—	296
48	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
49	Riluzole	—	298
50	Thioinosine Sulfhydryl analog of INOSINE that inhibits nucleoside transport across erythrocyte plasma membranes, and has immunosuppressive properties. It has been used similarly to MERCAPTOPURINE in	—	242

About the TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Pathway

The TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest pathway is catalogued in Reactome (ID: R-HSA-6804116) and involves 4 genes. In the BiohacksAI corpus, 155 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CCNA1, CCNE2, CDK2, TP53.