What compounds affect the Urea cycle pathway?

159 compounds in the BiohacksAI corpus have documented interactions with genes in the Urea cycle pathway (Reactome ID: R-HSA-70635). These compounds target 2 genes within this pathway.

What genes are in the Urea cycle pathway?

The Urea cycle pathway involves 2 genes. Key genes include: SIRT5, TP53.

Urea cycle

REACTOME PATHWAY

Reactome: R-HSA-706352 genes159 compounds

The Urea cycle pathway (Reactome ID: R-HSA-70635) involves 2 genes and is affected by 159 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

SIRT5 TP53

Compounds Affecting Urea cycle

#	Compound	Targets Hit	Studies
1	Hexachlorophene	—	300
2	alpha-Linolenic Acid	—	300
3	Ethidium	—	300
4	Ethinyl Estradiol	—	300
5	Azacitidine	—	298
6	Azacitidine	—	300
7	Methylene Blue	—	200
8	Bortezomib	—	300
9	Rotenone	—	300
10	Azathioprine	—	300
11	Cladribine	—	297
12	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
13	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
14	Cytarabine	—	297
15	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
16	Melphalan	—	300
17	Niclosamide	—	299
18	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
19	Methotrexate	—	289
20	Dactinomycin	—	297
21	Daunorubicin	—	298
22	Disulfiram	—	297
23	Glutaral	—	42
24	Vitamin K 3	—	300
25	Trifluridine	—	295
26	Quercetin	—	300
27	Axitinib	—	298
28	ninhydrin	—	300
29	o-Phthalaldehyde	—	300
30	Razoxane	—	154
31	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
32	plumbagin [Supplementary Concept]	—	300
33	Camptothecin	—	300
34	Reserpine	—	297
35	Genistein	—	300
36	Resveratrol	—	298
37	Ciclopirox	—	88
38	Clofarabine	—	298
39	cycloheximide	—	300
40	daph	—	2
41	Dinitrochlorobenzene	—	300
42	Estramustine	—	300
43	3-(1-(3-hydroxy-4-methoxyphenyl)methylidene)-6-methylchroman-4-one [Supplementary Concept]	—	1
44	Loratadine	—	296
45	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
46	Riluzole	—	298
47	Thioinosine Sulfhydryl analog of INOSINE that inhibits nucleoside transport across erythrocyte plasma membranes, and has immunosuppressive properties. It has been used similarly to MERCAPTOPURINE in	—	242
48	Trabectedin	—	297
49	Vorinostat	—	299
50	Clotrimazole	—	296

About the Urea cycle Pathway

The Urea cycle pathway is catalogued in Reactome (ID: R-HSA-70635) and involves 2 genes. In the BiohacksAI corpus, 159 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include SIRT5, TP53.