What compounds affect the The NLRP3 inflammasome pathway?

94 compounds in the BiohacksAI corpus have documented interactions with genes in the The NLRP3 inflammasome pathway (Reactome ID: R-HSA-844456). These compounds target 9 genes within this pathway.

What genes are in the The NLRP3 inflammasome pathway?

The The NLRP3 inflammasome pathway involves 9 genes. Key genes include: APP, CASP1, HSP90AB1, NFKB1, NFKB2, NLRP3, P2RX7, PANX1, RELA.

The NLRP3 inflammasome

REACTOME PATHWAY

Reactome: R-HSA-8444569 genes94 compounds

The The NLRP3 inflammasome pathway (Reactome ID: R-HSA-844456) involves 9 genes and is affected by 94 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

APP CASP1 HSP90AB1 NFKB1 NFKB2 NLRP3 P2RX7 PANX1 RELA

Compounds Affecting The NLRP3 inflammasome

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	Resveratrol	—	298
3	Bortezomib	—	300
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	Kaempferols	—	300
6	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
7	Disulfiram	—	297
8	Podophyllotoxin	—	14
9	Rutin	—	300
10	Withania	—	500
11	Hexachlorophene	—	300
12	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
13	tamarixetin	—	26
14	Trifluridine	—	295
15	withaferin	—	300
16	egcg	—	300
17	streptonigrin	—	299
18	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
19	caffeic acid	—	300
20	Ethinyl Estradiol	—	300
21	Thioridazine	—	35
22	Hydrocortisone	—	299
23	Cerulenin	—	300
24	Chlorpropamide	—	300
25	daph	—	2
26	Hydrocortisone	—	298
27	Lovastatin	—	300
28	ly294002	—	11
29	Promethazine	—	121
30	protriptyline	—	296
31	Sulfaphenazole	—	300
32	Triamcinolone	—	300
33	tyrphostin 1	—	1
34	tyrphostin ag 1478	—	4
35	Hesperidin	—	300
36	Methylene Blue	—	200
37	(N-methyl-C-11)-2-(4-methylamino-phenyl)-6-hydroxybenzothiazole [Supplementary Concept] neutral analog of amyloid-binding thioflavin-T (BTA) that crosses	—	300
38	Vitamin	—	295
39	2-Methoxyestradiol	—	300
40	arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from	—	300
41	Cladribine	—	297
42	Digitoxin	—	300
43	Digoxin	—	299
44	Edetic Acid	—	24
45	Catechin	—	300
46	Vanillic Acid	—	300
47	Ouabain	—	300
48	Quinic Acid	—	218
49	Retinaldehyde	—	300
50	Voriconazole	—	299

About the The NLRP3 inflammasome Pathway

The The NLRP3 inflammasome pathway is catalogued in Reactome (ID: R-HSA-844456) and involves 9 genes. In the BiohacksAI corpus, 94 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include APP, CASP1, HSP90AB1, NFKB1, NFKB2.