What compounds affect the Transcriptional regulation by RUNX3 pathway?

254 compounds in the BiohacksAI corpus have documented interactions with genes in the Transcriptional regulation by RUNX3 pathway (Reactome ID: R-HSA-8878159). These compounds target 51 genes within this pathway.

What genes are in the Transcriptional regulation by RUNX3 pathway?

The Transcriptional regulation by RUNX3 pathway involves 51 genes. Key genes include: ADRM1, BCL2L11, BRD2, CBFB, CREBBP, EP300, FOXO3, HDAC4, ITGA4, KAT2A.

Transcriptional regulation by RUNX3

REACTOME PATHWAY

Reactome: R-HSA-887815951 genes254 compounds

The Transcriptional regulation by RUNX3 pathway (Reactome ID: R-HSA-8878159) involves 51 genes and is affected by 254 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 BCL2L11 BRD2 CBFB CREBBP EP300 FOXO3 HDAC4 ITGA4 KAT2A KAT2B MDM2 MYC PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3+21 more

Compounds Affecting Transcriptional regulation by RUNX3

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Daunorubicin	—	298
4	Disulfiram	—	297
5	Nocodazole Nocodazole is	—	215
6	Colchicine	—	300
7	Ethidium	—	300
8	Hexachlorophene	—	300
9	Azacitidine	—	298
10	Azacitidine	—	300
11	Quercetin	—	300
12	Resveratrol	—	298
13	cycloheximide	—	300
14	Harmaline	—	300
15	Astemizole Antihistamine drug now withdrawn from	—	280
16	Anisomycin	—	247
17	egcg	—	300
18	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
19	Methylene Blue	—	200
20	Rotenone	—	300
21	Cladribine	—	297
22	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
23	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
24	Niclosamide	—	299
25	Dactinomycin	—	297
26	plumbagin [Supplementary Concept]	—	300
27	Camptothecin	—	300
28	Genistein	—	300
29	Ciclopirox	—	88
30	Dinitrochlorobenzene	—	300
31	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
32	Vorinostat	—	299
33	vinblastine sulfate	—	81
34	chrysin	—	300
35	Nisoldipine	—	297
36	Oxyphenbutazone	—	300
37	rafoxanide	—	172
38	Dasatinib	—	299
39	Emetine	—	298
40	tyrphostin 9	—	2
41	Tubercidin	—	300
42	Podophyllotoxin	—	14
43	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
44	Aurintricarboxylic Acid	—	184
45	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
46	Ethinyl Estradiol	—	300
47	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
48	Cytarabine	—	297
49	Melphalan	—	300
50	Methotrexate	—	289

About the Transcriptional regulation by RUNX3 Pathway

The Transcriptional regulation by RUNX3 pathway is catalogued in Reactome (ID: R-HSA-8878159) and involves 51 genes. In the BiohacksAI corpus, 254 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, BCL2L11, BRD2, CBFB, CREBBP.