What compounds affect the Aryl hydrocarbon receptor signalling pathway?

111 compounds in the BiohacksAI corpus have documented interactions with genes in the Aryl hydrocarbon receptor signalling pathway (Reactome ID: R-HSA-8937144). These compounds target 4 genes within this pathway.

What genes are in the Aryl hydrocarbon receptor signalling pathway?

The Aryl hydrocarbon receptor signalling pathway involves 4 genes. Key genes include: AHR, ARNT, HSP90AB1, PTGES3.

Aryl hydrocarbon receptor signalling

REACTOME PATHWAY

Reactome: R-HSA-89371444 genes111 compounds

The Aryl hydrocarbon receptor signalling pathway (Reactome ID: R-HSA-8937144) involves 4 genes and is affected by 111 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AHR ARNT HSP90AB1 PTGES3

Compounds Affecting Aryl hydrocarbon receptor signalling

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	gedunin	—	54
3	Carbaryl	—	300
4	Methylcholanthrene	—	300
5	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
6	Diuron	—	300
7	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
8	Ethidium	—	300
9	Diflubenzuron	—	300
10	Edaravone	—	298
11	Leflunomide	—	297
12	Linuron	—	299
13	Reserpine	—	297
14	Genistein	—	300
15	Thyroxine	—	994
16	Methylene Blue	—	200
17	Carboxin	—	174
18	Secologanin Tryptamine Alkaloids Compounds formed by condensation of secologanin with tryptamine resulting in	—	300
19	Isoniazid Antibacterial agent used primarily as	—	299
20	Vitamin K 3	—	300
21	Niclosamide	—	299
22	Phenelzine	—	2
23	Sulindac	—	297
24	Thyroxine	—	300
25	chrysin	—	300
26	Kaempferols	—	300
27	propyl gallate	—	261
28	Resveratrol	—	298
29	Nisoldipine	—	297
30	Picloram	—	297
31	Triiodothyronine	—	300
32	Night Vision Function of	—	56
33	vinpocetine	—	299
34	Vitamin K 2	—	300
35	2-Acetylaminofluorene	—	300
36	amlexanox	—	96
37	Axitinib	—	298
38	Azathioprine	—	300
39	Clobetasol	—	299
40	clonixin	—	43
41	Clotrimazole	—	296
42	Ethoxyquin Antioxidant; also	—	180
43	Febuxostat	—	297
44	Imatinib Mesylate	—	300
45	indirubin	—	300
46	Lumefantrine	—	299
47	methoprene	—	300
48	Methoxsalen	—	300
49	Naphazoline	—	298
50	Nicergoline	—	300

About the Aryl hydrocarbon receptor signalling Pathway

The Aryl hydrocarbon receptor signalling pathway is catalogued in Reactome (ID: R-HSA-8937144) and involves 4 genes. In the BiohacksAI corpus, 111 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AHR, ARNT, HSP90AB1, PTGES3.