What compounds affect the RUNX3 regulates CDKN1A transcription pathway?

178 compounds in the BiohacksAI corpus have documented interactions with genes in the RUNX3 regulates CDKN1A transcription pathway (Reactome ID: R-HSA-8941855). These compounds target 2 genes within this pathway.

What genes are in the RUNX3 regulates CDKN1A transcription pathway?

The RUNX3 regulates CDKN1A transcription pathway involves 2 genes. Key genes include: SMAD3, TP53.

RUNX3 regulates CDKN1A transcription

REACTOME PATHWAY

Reactome: R-HSA-89418552 genes178 compounds

The RUNX3 regulates CDKN1A transcription pathway (Reactome ID: R-HSA-8941855) involves 2 genes and is affected by 178 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

SMAD3 TP53

Compounds Affecting RUNX3 regulates CDKN1A transcription

#	Compound	Targets Hit	Studies
1	Ethidium	—	300
2	Ethinyl Estradiol	—	300
3	Hexachlorophene	—	300
4	Azacitidine	—	298
5	Azacitidine	—	300
6	Methylene Blue	—	200
7	Bortezomib	—	300
8	Rotenone	—	300
9	Cladribine	—	297
10	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
11	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
12	Dactinomycin	—	297
13	Daunorubicin	—	298
14	Disulfiram	—	297
15	Quercetin	—	300
16	o-Phthalaldehyde	—	300
17	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
18	Ciclopirox	—	88
19	cycloheximide	—	300
20	Dinitrochlorobenzene	—	300
21	Loratadine	—	296
22	vinblastine sulfate	—	81
23	chrysin	—	300
24	Digitoxin	—	300
25	Idazoxan	—	300
26	Nisoldipine	—	297
27	Nocodazole Nocodazole is	—	215
28	Oxyphenbutazone	—	300
29	Perphenazine	—	297
30	triflupromazine hydrochloride	—	12
31	Vincristine	—	299
32	Astemizole Antihistamine drug now withdrawn from	—	280
33	Colchicine	—	300
34	Dasatinib	—	299
35	Emetine	—	298
36	Salmeterol Xinafoate	—	227
37	Azathioprine	—	300
38	Cytarabine	—	297
39	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
40	Melphalan	—	300
41	Niclosamide	—	299
42	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
43	Methotrexate	—	289
44	Glutaral	—	42
45	Vitamin K 3	—	300
46	Trifluridine	—	295
47	Axitinib	—	298
48	ninhydrin	—	300
49	Razoxane	—	154
50	plumbagin [Supplementary Concept]	—	300

About the RUNX3 regulates CDKN1A transcription Pathway

The RUNX3 regulates CDKN1A transcription pathway is catalogued in Reactome (ID: R-HSA-8941855) and involves 2 genes. In the BiohacksAI corpus, 178 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include SMAD3, TP53.