What genes are in the Regulation of RUNX3 expression and activity pathway?

The Regulation of RUNX3 expression and activity pathway involves 36 genes. Key genes include: ADRM1, CBFB, EP300, MDM2, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6.

Regulation of RUNX3 expression and activity

Q: What compounds affect the Regulation of RUNX3 expression and activity pathway?

84 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulation of RUNX3 expression and activity pathway (Reactome ID: R-HSA-8941858). These compounds target 36 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-894185836 genes84 compounds

The Regulation of RUNX3 expression and activity pathway (Reactome ID: R-HSA-8941858) involves 36 genes and is affected by 84 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 CBFB EP300 MDM2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2+6 more

Compounds Affecting Regulation of RUNX3 expression and activity

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Niclosamide	—	299
4	Disulfiram	—	297
5	egcg	—	300
6	Quercetin	—	300
7	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
8	Harmaline	—	300
9	Digoxin	—	299
10	Calcimycin	—	216
11	cycloheximide	—	300
12	Cytarabine	—	297
13	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
14	Tubercidin	—	300
15	Anisomycin	—	247
16	Astemizole Antihistamine drug now withdrawn from	—	280
17	Azacitidine	—	298
18	Azacitidine	—	300
19	Chlorhexidine	—	299
20	Ciclopirox	—	88
21	Cladribine	—	297
22	Colchicine	—	300
23	colchine	—	2
24	Demecolcine	—	246
25	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
26	Fluspirilene	—	74
27	gedunin	—	54
28	Hexachlorophene	—	300
29	lidoflazine	—	278
30	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
31	Nisoldipine	—	297
32	Nocodazole Nocodazole is	—	215
33	Ouabain	—	300
34	paxilline	—	42
35	Podophyllotoxin	—	14
36	rafoxanide	—	172
37	streptonigrin	—	299
38	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
39	Trifluridine	—	295
40	tyrphostin 9	—	2
41	vinblastine sulfate	—	81
42	Methylene Blue	—	200
43	Sertraline	—	1,000
44	Simvastatin	—	1,000
45	Ursolic Acid	—	300
46	Methotrexate	—	289
47	Aripiprazole	—	298
48	cardamonin	—	180
49	dihydrorotenone	—	13
50	Dinitrochlorobenzene	—	300

About the Regulation of RUNX3 expression and activity Pathway

The Regulation of RUNX3 expression and activity pathway is catalogued in Reactome (ID: R-HSA-8941858) and involves 36 genes. In the BiohacksAI corpus, 84 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, CBFB, EP300, MDM2, PSMA1.