Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

Q: What compounds affect the Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation pathway?

155 compounds in the BiohacksAI corpus have documented interactions with genes in the Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation pathway (Reactome ID: R-HSA-8950505). These compounds target 9 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-89505059 genes155 compounds

The Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation pathway (Reactome ID: R-HSA-8950505) involves 9 genes and is affected by 155 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ANXA2 CA1 CDC42 CFL1 GSTO1 IFNG MIF PDCD4 SOD1

Compounds Affecting Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

#	Compound	Targets Hit	Studies
1	Hexachlorophene	—	300
2	Bortezomib	—	300
3	Quercetin	—	300
4	Clotrimazole	—	296
5	Histamine	—	300
6	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
7	Catechin	—	300
8	Oxytetracycline	—	300
9	Tetracycline	—	300
10	Dacarbazine	—	299
11	Homoharringtonine Semisynthetic derivative of harringtonine that acts as	—	300
12	2-Methoxyestradiol	—	300
13	Anisomycin	—	247
14	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
15	Camptothecin	—	300
16	cycloheximide	—	300
17	Dasatinib	—	299
18	Desoxycorticosterone Acetate	—	300
19	tyrphostin 9	—	2
20	Azathioprine	—	300
21	Crizotinib	—	298
22	Econazole	—	299
23	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
24	Nocodazole Nocodazole is	—	215
25	Sorafenib	—	300
26	Ursolic Acid	—	300
27	Afatinib	—	297
28	alsterpaullone	—	12
29	Chlorhexidine	—	299
30	Cholecalciferol Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of	—	299
31	Clofarabine	—	298
32	Dactinomycin	—	297
33	darapladib [Supplementary Concept]	—	44
34	Daunorubicin	—	298
35	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
36	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
37	Epirubicin	—	300
38	Estrone	—	300
39	Ethinyl Estradiol	—	300
40	Fulvestrant	—	295
41	Idarubicin	—	299
42	Irinotecan	—	298
43	Levonorgestrel	—	292
44	Miconazole	—	298
45	Nandrolone C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less	—	300
46	Niclosamide	—	299
47	Norgestrel	—	300
48	Novobiocin	—	300
49	Perphenazine	—	297
50	Podophyllotoxin	—	14

About the Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Pathway

The Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation pathway is catalogued in Reactome (ID: R-HSA-8950505) and involves 9 genes. In the BiohacksAI corpus, 155 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ANXA2, CA1, CDC42, CFL1, GSTO1.