NOTCH4 Intracellular Domain Regulates Transcription

Q: What compounds affect the NOTCH4 Intracellular Domain Regulates Transcription pathway?

90 compounds in the BiohacksAI corpus have documented interactions with genes in the NOTCH4 Intracellular Domain Regulates Transcription pathway (Reactome ID: R-HSA-9013695). These compounds target 6 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-90136956 genes90 compounds

The NOTCH4 Intracellular Domain Regulates Transcription pathway (Reactome ID: R-HSA-9013695) involves 6 genes and is affected by 90 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CREBBP EP300 FLT4 KAT2A KAT2B SMAD3

Compounds Affecting NOTCH4 Intracellular Domain Regulates Transcription

#	Compound	Targets Hit	Studies
1	egcg	—	300
2	alsterpaullone	—	12
3	kenpaullone	—	8
4	Colchicine	—	300
5	Hexachlorophene	—	300
6	Nocodazole Nocodazole is	—	215
7	plumbagin [Supplementary Concept]	—	300
8	Calcimycin	—	216
9	cycloheximide	—	300
10	Anisomycin	—	247
11	Azacitidine	—	298
12	Azacitidine	—	300
13	Disulfiram	—	297
14	Nisoldipine	—	297
15	Tubercidin	—	300
16	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
17	Kaempferols	—	300
18	Quercetin	—	300
19	cardamonin	—	180
20	Dactinomycin	—	297
21	Danazol	—	298
22	Dasatinib	—	299
23	Dinitrochlorobenzene	—	300
24	Ethidium	—	300
25	Flutamide	—	298
26	Loratadine	—	296
27	Oxyphenbutazone	—	300
28	Podophyllotoxin	—	14
29	vinblastine sulfate	—	81
30	Vincristine	—	299
31	chrysin	—	300
32	Fluoxetine	—	1,000
33	Methylene Blue	—	200
34	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
35	Astemizole Antihistamine drug now withdrawn from	—	280
36	Bortezomib	—	300
37	Celecoxib	—	295
38	Ciclopirox	—	88
39	Cladribine	—	297
40	Daunorubicin	—	298
41	Digitoxin	—	300
42	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
43	Dithiazanine 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium.	—	135
44	Domperidone	—	299
45	Emetine	—	298
46	Equilin	—	216
47	Ethinyl Estradiol	—	300
48	Ezetimibe	—	296
49	Fluspirilene	—	74
50	Idazoxan	—	300

About the NOTCH4 Intracellular Domain Regulates Transcription Pathway

The NOTCH4 Intracellular Domain Regulates Transcription pathway is catalogued in Reactome (ID: R-HSA-9013695) and involves 6 genes. In the BiohacksAI corpus, 90 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CREBBP, EP300, FLT4, KAT2A, KAT2B.