What compounds affect the Biosynthesis of maresin-like SPMs pathway?

545 compounds in the BiohacksAI corpus have documented interactions with genes in the Biosynthesis of maresin-like SPMs pathway (Reactome ID: R-HSA-9027307). These compounds target 6 genes within this pathway.

What genes are in the Biosynthesis of maresin-like SPMs pathway?

The Biosynthesis of maresin-like SPMs pathway involves 6 genes. Key genes include: CYP1A2, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP3A4.

Biosynthesis of maresin-like SPMs

REACTOME PATHWAY

Reactome: R-HSA-90273076 genes545 compounds

The Biosynthesis of maresin-like SPMs pathway (Reactome ID: R-HSA-9027307) involves 6 genes and is affected by 545 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CYP1A2 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP3A4

Compounds Affecting Biosynthesis of maresin-like SPMs

#	Compound	Targets Hit	Studies
1	Clotrimazole	—	296
2	Chlorhexidine	—	299
3	Methoxsalen	—	300
4	Kaempferols	—	300
5	Amoxapine	—	259
6	Danazol	—	298
7	Piribedil	—	300
8	Tolazamide	—	169
9	Ethoxyquin Antioxidant; also	—	180
10	Piperonyl Butoxide	—	300
11	Methylene Blue	—	200
12	Ethidium	—	300
13	Melphalan	—	300
14	Vitamin K 3	—	300
15	Miconazole	—	298
16	oxatomide [Supplementary Concept] structure;	—	128
17	Phenelzine	—	2
18	Reserpine	—	297
19	Sulindac	—	297
20	Melatonin	—	297
21	Flutamide	—	298
22	Fluvoxamine	—	297
23	Nisoldipine	—	297
24	Phenelzine	—	297
25	Phenylthiourea Phenylthiourea is	—	300
26	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
27	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	1,000
28	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	293
29	amlexanox	—	96
30	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
31	Lumefantrine	—	299
32	Nialamide	—	300
33	Niclosamide	—	299
34	Pueraria	—	300
35	Simvastatin	—	1,000
36	Axitinib	—	298
37	Carbaryl	—	300
38	Disulfiram	—	297
39	Edaravone	—	298
40	Ethanolamine	—	300
41	Farnesol	—	300
42	Iodoacetamide	—	300
43	Isoniazid Antibacterial agent used primarily as	—	299
44	Leflunomide	—	297
45	pd98059	—	7
46	Propanil	—	293
47	Rotenone	—	300
48	sesamol	—	293
49	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
50	cbd	—	298

About the Biosynthesis of maresin-like SPMs Pathway

The Biosynthesis of maresin-like SPMs pathway is catalogued in Reactome (ID: R-HSA-9027307) and involves 6 genes. In the BiohacksAI corpus, 545 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CYP1A2, CYP2C8, CYP2C9, CYP2D6, CYP2E1.