What compounds affect the Late endosomal microautophagy pathway?

100 compounds in the BiohacksAI corpus have documented interactions with genes in the Late endosomal microautophagy pathway (Reactome ID: R-HSA-9615710). These compounds target 4 genes within this pathway.

What genes are in the Late endosomal microautophagy pathway?

The Late endosomal microautophagy pathway involves 4 genes. Key genes include: CFTR, HBB, HDAC6, HSPA8.

Late endosomal microautophagy

REACTOME PATHWAY

Reactome: R-HSA-96157104 genes100 compounds

The Late endosomal microautophagy pathway (Reactome ID: R-HSA-9615710) involves 4 genes and is affected by 100 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CFTR HBB HDAC6 HSPA8

Compounds Affecting Late endosomal microautophagy

#	Compound	Targets Hit	Studies
1	Genistein	—	300
2	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
3	Vorinostat	—	299
4	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
5	Vitamin K 3	—	300
6	Hexachlorophene	—	300
7	scriptaid	—	53
8	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
9	Camptothecin	—	300
10	Anisomycin	—	247
11	cycloheximide	—	300
12	kenpaullone	—	8
13	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
14	Hydrocortisone	—	299
15	Betamethasone	—	299
16	Bumetanide	—	299
17	Chlorthalidone	—	299
18	Ethidium	—	300
19	Hydrocortisone	—	298
20	Cervugid [Supplementary Concept]	—	300
21	Medroxyprogesterone Acetate	—	299
22	Mestranol	—	300
23	Nisoldipine	—	297
24	Quinestrol	—	194
25	Budesonide	—	1,000
26	Methylene Blue	—	200
27	Prednisolone	—	1,000
28	6-Aminonicotinamide	—	300
29	alsterpaullone	—	12
30	Hyoscyamine	—	296
31	Beclomethasone	—	300
32	Carbazilquinone	—	48
33	Carbidopa	—	298
34	cardamonin	—	180
35	Desoximetasone	—	86
36	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
37	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
38	Digoxin	—	299
39	Dinitrochlorobenzene	—	300
40	Disulfiram	—	297
41	Flumethasone	—	179
42	Fluocinolone Acetonide	—	295
43	Fluorometholone	—	299
44	Flurandrenolone	—	65
45	gamma-Linolenic Acid	—	300
46	Glyburide	—	298
47	Halcinonide	—	88
48	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	—	115
49	Medroxyprogesterone	—	298
50	Melengestrol Acetate	—	300

About the Late endosomal microautophagy Pathway

The Late endosomal microautophagy pathway is catalogued in Reactome (ID: R-HSA-9615710) and involves 4 genes. In the BiohacksAI corpus, 100 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CFTR, HBB, HDAC6, HSPA8.