What compounds affect the Transcriptional Regulation by NPAS4 pathway?

232 compounds in the BiohacksAI corpus have documented interactions with genes in the Transcriptional Regulation by NPAS4 pathway (Reactome ID: R-HSA-9634815). These compounds target 15 genes within this pathway.

What genes are in the Transcriptional Regulation by NPAS4 pathway?

The Transcriptional Regulation by NPAS4 pathway involves 15 genes. Key genes include: AGO2, ARNT, CDK5, CDK5R1, CREBBP, FOS, GEM, INS, MAPK1, MAPK3.

Transcriptional Regulation by NPAS4

REACTOME PATHWAY

Reactome: R-HSA-963481515 genes232 compounds

The Transcriptional Regulation by NPAS4 pathway (Reactome ID: R-HSA-9634815) involves 15 genes and is affected by 232 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AGO2 ARNT CDK5 CDK5R1 CREBBP FOS GEM INS MAPK1 MAPK3 MDM2 NR3C1 PLK2 RET XPO1

Compounds Affecting Transcriptional Regulation by NPAS4

#	Compound	Targets Hit	Studies
1	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
2	sp600125	—	117
3	alsterpaullone	—	12
4	kenpaullone	—	8
5	Sorafenib	—	300
6	Digoxin	—	299
7	chrysin	—	300
8	plumbagin [Supplementary Concept]	—	300
9	fisetin	—	78
10	Progesterone	—	299
11	Azacitidine	—	298
12	Azacitidine	—	300
13	cycloheximide	—	300
14	Spironolactone	—	298
15	Simvastatin	—	1,000
16	Lithocholic Acid	—	300
17	Vorinostat	—	299
18	Clotrimazole	—	296
19	Digitoxin	—	300
20	Lovastatin	—	300
21	Nisoldipine	—	297
22	Genistein	—	300
23	Ciclopirox	—	88
24	Dasatinib	—	299
25	Ouabain	—	300
26	Calcimycin	—	216
27	Colchicine	—	300
28	Nocodazole Nocodazole is	—	215
29	streptonigrin	—	299
30	Thioridazine	—	35
31	pd98059	—	7
32	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
33	trametinib	—	296
34	withaferin	—	300
35	indirubin	—	300
36	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
37	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
38	egcg	—	300
39	Prednisolone	—	1,000
40	Hydrocortisone	—	299
41	Corticosterone	—	300
42	Hydrocortisone	—	298
43	Budesonide	—	1,000
44	Triamcinolone Acetonide	—	300
45	Megestrol Acetate Megestrol acetate is	—	300
46	Methyltestosterone	—	300
47	Prednisone	—	298
48	Triamcinolone	—	300
49	Medroxyprogesterone Acetate	—	299
50	Methylprednisolone	—	299

About the Transcriptional Regulation by NPAS4 Pathway

The Transcriptional Regulation by NPAS4 pathway is catalogued in Reactome (ID: R-HSA-9634815) and involves 15 genes. In the BiohacksAI corpus, 232 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AGO2, ARNT, CDK5, CDK5R1, CREBBP.