What compounds affect the Formation of axial mesoderm pathway?

91 compounds in the BiohacksAI corpus have documented interactions with genes in the Formation of axial mesoderm pathway (Reactome ID: R-HSA-9796292). These compounds target 4 genes within this pathway.

What genes are in the Formation of axial mesoderm pathway?

The Formation of axial mesoderm pathway involves 4 genes. Key genes include: SMAD2, SMAD3, TEAD4, YAP1.

Formation of axial mesoderm

REACTOME PATHWAY

Reactome: R-HSA-97962924 genes91 compounds

The Formation of axial mesoderm pathway (Reactome ID: R-HSA-9796292) involves 4 genes and is affected by 91 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

SMAD2 SMAD3 TEAD4 YAP1

Compounds Affecting Formation of axial mesoderm

#	Compound	Targets Hit	Studies
1	cycloheximide	—	300
2	Azacitidine	—	298
3	Azacitidine	—	300
4	Colchicine	—	300
5	Dactinomycin	—	297
6	Podophyllotoxin	—	14
7	Daunorubicin	—	298
8	Emetine	—	298
9	Nocodazole Nocodazole is	—	215
10	Rotenone	—	300
11	Anisomycin	—	247
12	Disulfiram	—	297
13	Nisoldipine	—	297
14	Tubercidin	—	300
15	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
16	Kaempferols	—	300
17	Quercetin	—	300
18	Danazol	—	298
19	Dasatinib	—	299
20	Dinitrochlorobenzene	—	300
21	Ethidium	—	300
22	Flutamide	—	298
23	Loratadine	—	296
24	Oxyphenbutazone	—	300
25	vinblastine sulfate	—	81
26	Vincristine	—	299
27	chrysin	—	300
28	egcg	—	300
29	Fluoxetine	—	1,000
30	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
31	Astemizole Antihistamine drug now withdrawn from	—	280
32	Bortezomib	—	300
33	Celecoxib	—	295
34	Ciclopirox	—	88
35	Cladribine	—	297
36	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
37	Domperidone	—	299
38	Equilin	—	216
39	Ethinyl Estradiol	—	300
40	Ezetimibe	—	296
41	Idazoxan	—	300
42	Lynestrenol	—	299
43	Masoprocol	—	300
44	o-Phthalaldehyde	—	300
45	Perphenazine	—	297
46	pivampicillin	—	275
47	Promethazine	—	121
48	Salmeterol Xinafoate	—	227
49	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
50	Sulbactam	—	299

About the Formation of axial mesoderm Pathway

The Formation of axial mesoderm pathway is catalogued in Reactome (ID: R-HSA-9796292) and involves 4 genes. In the BiohacksAI corpus, 91 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include SMAD2, SMAD3, TEAD4, YAP1.