What compounds affect the NFE2L2 regulating TCA cycle genes pathway?

229 compounds in the BiohacksAI corpus have documented interactions with genes in the NFE2L2 regulating TCA cycle genes pathway (Reactome ID: R-HSA-9818025). These compounds target 2 genes within this pathway.

What genes are in the NFE2L2 regulating TCA cycle genes pathway?

The NFE2L2 regulating TCA cycle genes pathway involves 2 genes. Key genes include: IDH1, NFE2L2.

NFE2L2 regulating TCA cycle genes

REACTOME PATHWAY

Reactome: R-HSA-98180252 genes229 compounds

The NFE2L2 regulating TCA cycle genes pathway (Reactome ID: R-HSA-9818025) involves 2 genes and is affected by 229 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

IDH1 NFE2L2

Compounds Affecting NFE2L2 regulating TCA cycle genes

#	Compound	Targets Hit	Studies
1	Azacitidine	—	298
2	Azacitidine	—	300
3	Methylene Blue	—	200
4	Azathioprine	—	300
5	Niclosamide	—	299
6	vinblastine sulfate	—	81
7	Digitoxin	—	300
8	Digoxin	—	299
9	Hexachlorophene	—	300
10	Methotrexate	—	289
11	Dinitrochlorobenzene	—	300
12	Nisoldipine	—	297
13	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
14	Simvastatin	—	1,000
15	Mometasone Furoate	—	292
16	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
17	Chlorhexidine	—	299
18	clofilium tosylate	—	4
19	Lovastatin	—	300
20	Resveratrol	—	298
21	Colchicine	—	300
22	Vitamin	—	295
23	Genistein	—	300
24	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
25	alpha-Linolenic Acid	—	300
26	Oxymetholone	—	298
27	Rotenone	—	300
28	Ethoxyquin Antioxidant; also	—	180
29	Nitrofurazone	—	300
30	Quercetin	—	300
31	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
32	Mestranol	—	300
33	methoprene	—	300
34	Phenelzine	—	2
35	chrysin	—	300
36	alyssin [Supplementary Concept]	—	300
37	Flutamide	—	298
38	Linoleic Acid	—	300
39	Vitamin K 3	—	300
40	Nitrofurantoin	—	297
41	Ouabain	—	300
42	Podophyllotoxin	—	14
43	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
44	Toxaphene	—	299
45	DEAD-box RNA Helicases	—	169
46	Thioctic Acid	—	298
47	amlexanox	—	96
48	Bortezomib	—	300
49	Chlormadinone Acetate	—	300
50	Ethidium	—	300

About the NFE2L2 regulating TCA cycle genes Pathway

The NFE2L2 regulating TCA cycle genes pathway is catalogued in Reactome (ID: R-HSA-9818025) and involves 2 genes. In the BiohacksAI corpus, 229 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include IDH1, NFE2L2.