What compounds affect the Regulation of NFE2L2 gene expression pathway?

227 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulation of NFE2L2 gene expression pathway (Reactome ID: R-HSA-9818749). These compounds target 6 genes within this pathway.

What genes are in the Regulation of NFE2L2 gene expression pathway?

The Regulation of NFE2L2 gene expression pathway involves 6 genes. Key genes include: CREBBP, EP300, MYC, NFE2L2, NFKB1, RELA.

Regulation of NFE2L2 gene expression

REACTOME PATHWAY

Reactome: R-HSA-98187496 genes227 compounds

The Regulation of NFE2L2 gene expression pathway (Reactome ID: R-HSA-9818749) involves 6 genes and is affected by 227 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CREBBP EP300 MYC NFE2L2 NFKB1 RELA

Compounds Affecting Regulation of NFE2L2 gene expression

#	Compound	Targets Hit	Studies
1	Resveratrol	—	298
2	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
3	Quercetin	—	300
4	Podophyllotoxin	—	14
5	Bortezomib	—	300
6	Kaempferols	—	300
7	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
8	Trifluridine	—	295
9	Colchicine	—	300
10	vinblastine sulfate	—	81
11	Hexachlorophene	—	300
12	Nocodazole Nocodazole is	—	215
13	Oleanolic Acid	—	300
14	Disulfiram	—	297
15	Hydrocortisone	—	299
16	Hydrocortisone	—	298
17	Lovastatin	—	300
18	ly294002	—	11
19	Papaverine	—	299
20	Triamcinolone	—	300
21	egcg	—	300
22	Rutin	—	300
23	Withania	—	500
24	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
25	tamarixetin	—	26
26	withaferin	—	300
27	plumbagin [Supplementary Concept]	—	300
28	Vitamin	—	295
29	Azacitidine	—	298
30	Azacitidine	—	300
31	Genistein	—	300
32	alpha-Linolenic Acid	—	300
33	Oxymetholone	—	298
34	Rotenone	—	300
35	Methylene Blue	—	200
36	Ethoxyquin Antioxidant; also	—	180
37	Nitrofurazone	—	300
38	Azathioprine	—	300
39	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
40	Mestranol	—	300
41	methoprene	—	300
42	Niclosamide	—	299
43	Phenelzine	—	2
44	chrysin	—	300
45	alyssin [Supplementary Concept]	—	300
46	Digitoxin	—	300
47	Digoxin	—	299
48	Flutamide	—	298
49	Linoleic Acid	—	300
50	Vitamin K 3	—	300

About the Regulation of NFE2L2 gene expression Pathway

The Regulation of NFE2L2 gene expression pathway is catalogued in Reactome (ID: R-HSA-9818749) and involves 6 genes. In the BiohacksAI corpus, 227 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CREBBP, EP300, MYC, NFE2L2, NFKB1.