What compounds affect the Zygotic genome activation (ZGA) pathway?

177 compounds in the BiohacksAI corpus have documented interactions with genes in the Zygotic genome activation (ZGA) pathway (Reactome ID: R-HSA-9819196). These compounds target 6 genes within this pathway.

What genes are in the Zygotic genome activation (ZGA) pathway?

The Zygotic genome activation (ZGA) pathway involves 6 genes. Key genes include: CREBBP, EP300, KDM4E, TEAD4, TP53, YAP1.

Zygotic genome activation (ZGA)

REACTOME PATHWAY

Reactome: R-HSA-98191966 genes177 compounds

The Zygotic genome activation (ZGA) pathway (Reactome ID: R-HSA-9819196) involves 6 genes and is affected by 177 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CREBBP EP300 KDM4E TEAD4 TP53 YAP1

Compounds Affecting Zygotic genome activation (ZGA)

#	Compound	Targets Hit	Studies
1	Nocodazole Nocodazole is	—	215
2	Colchicine	—	300
3	Azacitidine	—	298
4	Azacitidine	—	300
5	Rotenone	—	300
6	Dactinomycin	—	297
7	Daunorubicin	—	298
8	plumbagin [Supplementary Concept]	—	300
9	Camptothecin	—	300
10	Genistein	—	300
11	Resveratrol	—	298
12	cycloheximide	—	300
13	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
14	Benzalkonium Compounds	—	299
15	celastrol	—	300
16	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
17	Pueraria	—	300
18	Antimycin	—	300
19	Emetine	—	298
20	Thapsigargin	—	300
21	Tilorone	—	300
22	Tripterygium	—	300
23	tyrphostin 9	—	2
24	Ethidium	—	300
25	Ethinyl Estradiol	—	300
26	Hexachlorophene	—	300
27	Methylene Blue	—	200
28	Bortezomib	—	300
29	Azathioprine	—	300
30	Cladribine	—	297
31	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
32	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
33	Cytarabine	—	297
34	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
35	Melphalan	—	300
36	Niclosamide	—	299
37	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
38	Methotrexate	—	289
39	Disulfiram	—	297
40	Glutaral	—	42
41	Vitamin K 3	—	300
42	Trifluridine	—	295
43	Quercetin	—	300
44	Axitinib	—	298
45	ninhydrin	—	300
46	o-Phthalaldehyde	—	300
47	Razoxane	—	154
48	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
49	Reserpine	—	297
50	Ciclopirox	—	88

About the Zygotic genome activation (ZGA) Pathway

The Zygotic genome activation (ZGA) pathway is catalogued in Reactome (ID: R-HSA-9819196) and involves 6 genes. In the BiohacksAI corpus, 177 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CREBBP, EP300, KDM4E, TEAD4, TP53.