Factors involved in megakaryocyte development and platelet production

Q: What compounds affect the Factors involved in megakaryocyte development and platelet production pathway?

210 compounds in the BiohacksAI corpus have documented interactions with genes in the Factors involved in megakaryocyte development and platelet production pathway (Reactome ID: R-HSA-983231). These compounds target 34 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-98323134 genes210 compounds

The Factors involved in megakaryocyte development and platelet production pathway (Reactome ID: R-HSA-983231) involves 34 genes and is affected by 210 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 CDC42 CDK2 CDK5 HBB HDAC1 HDAC2 IFNB1 JAK2 KDM1A KIFC1 PRKACA PRKACB PRKACG RACGAP1 TP53 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3E TUBA4A TUBA8 TUBAL3 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B+4 more

Compounds Affecting Factors involved in megakaryocyte development and platelet production

#	Compound	Targets Hit	Studies
1	Nocodazole Nocodazole is	—	215
2	Colchicine	—	300
3	Vorinostat	—	299
4	Noscapine	—	300
5	Vincristine	—	299
6	vinblastine sulfate	—	81
7	Demecolcine	—	246
8	Podophyllotoxin	—	14
9	Maytansine	—	300
10	Camptothecin	—	300
11	Bortezomib	—	300
12	Daunorubicin	—	298
13	sp600125	—	117
14	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
15	kenpaullone	—	8
16	hydroxyfasudil [Supplementary Concept]	—	11
17	Azacitidine	—	298
18	Azacitidine	—	300
19	Methylene Blue	—	200
20	Azathioprine	—	300
21	Quercetin	—	300
22	Genistein	—	300
23	triolimus [Supplementary Concept]	—	33
24	Adenosine Triphosphate	—	300
25	Dasatinib	—	299
26	Tripterygium	—	300
27	Sorafenib	—	300
28	alsterpaullone	—	12
29	Cladribine	—	297
30	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
31	Cytarabine	—	297
32	Dactinomycin	—	297
33	Disulfiram	—	297
34	Vitamin K 3	—	300
35	Trifluridine	—	295
36	Axitinib	—	298
37	cycloheximide	—	300
38	3-(1-(3-hydroxy-4-methoxyphenyl)methylidene)-6-methylchroman-4-one [Supplementary Concept]	—	1
39	Trabectedin	—	297
40	chrysin	—	300
41	celastrol	—	300
42	Digitoxin	—	300
43	Digoxin	—	299
44	Feprazone	—	63
45	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
46	Idarubicin	—	299
47	Pueraria	—	300
48	Sertraline	—	1,000
49	Warfarin	—	1,000
50	Astemizole Antihistamine drug now withdrawn from	—	280

About the Factors involved in megakaryocyte development and platelet production Pathway

The Factors involved in megakaryocyte development and platelet production pathway is catalogued in Reactome (ID: R-HSA-983231) and involves 34 genes. In the BiohacksAI corpus, 210 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, CDC42, CDK2, CDK5, HBB.