What compounds target SC6A3?

BiohacksAI has identified 283 compounds that interact with SC6A3 (Sodium-dependent dopamine transporter). Top compounds include: bdb win 35428 chembl2079586, bdb cbqgyudmjhnjbx, bdb chembl120901 3 naphthalen 2 yl 8 oxa bicyclo 3 2 1 oct 2 ene 2 carboxylic acid m, bdb 3 3 4 dichloro phenyl 8 methyl 8 aza bicyclo 3 2 1 oct 2 ene 2 carboxylic acid m, bdb kwgrbvopplscsi. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is SC6A3 (Sodium-dependent dopamine transporter)?

SC6A3 is Sodium-dependent dopamine transporter. It is a molecular target for 283 compounds documented in PubMed bioassay data.

SC6A3

MOLECULAR TARGET

Sodium-dependent dopamine transporter

283 compounds

SC6A3 (Sodium-dependent dopamine transporter) is targeted by 283 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting SC6A3

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	bdb win 35428 chembl2079586	1.79	5
2	bdb cbqgyudmjhnjbx	1.61	4
3	bdb chembl120901 3 naphthalen 2 yl 8 oxa bicyclo 3 2 1 oct 2 ene 2 carboxylic acid m	1.39	3
4	bdb 3 3 4 dichloro phenyl 8 methyl 8 aza bicyclo 3 2 1 oct 2 ene 2 carboxylic acid m	1.39	3
5	bdb kwgrbvopplscsi	1.10	2
6	bdb 3 4 z 2 iodo vinyl phenyl 8 aza bicyclo 3 2 1 octane 2 carboxylic acid methyl es	1.10	2
7	bdb chembl312037 2s 3s methyl 8 methyl 3 p tolyl 8 aza bicyclo 3 2 1 octane 2 carbox	1.10	2
8	bdb 3 3 4 dichloro phenyl 8 aza bicyclo 3 2 1 octane 2 carboxylic acid methyl ester	1.10	2
9	bdb 3 3 4 dichloro phenyl bicyclo 3 2 1 oct 2 ene 2 carboxylic acid methyl ester 1r	1.10	2
10	bdb 3 4 fluoro phenyl 8 methyl 8 aza bicyclo 3 2 1 oct 2 ene 2 carboxylic acid methy	1.10	2
11	bdb 8 methyl 3 naphthalen 2 yl 8 aza bicyclo 3 2 1 oct 2 ene 2 carboxylic acid methy	1.10	2
12	bdb 8 methyl 3 naphthalen 2 yl 8 aza bicyclo 3 2 1 octane 2 carboxylic acid methyl e	1.10	2
13	bdb chembl1790051 chembl83729 win 35065 2	1.10	2
14	bdb chembl2205811	0.69	1
15	bdb n 2 3 fluorophenyl ethyl 8 aminopentacyclo 5 4 0 02 6 03 10 05 9 undecane chembl	0.69	1
16	bdb chembl2205813	0.69	1
17	bdb n 2 3 fluorophenyl ethyl n methyl 8 aminopentacyclo 5 4 0 02 6 03 10 05 9 undeca	0.69	1
18	bdb 1 10 di 3beta 4 thiophene 3 yl phenyl tropane 2bcarbonyl amino decane chembl5957	0.69	1
19	bdb 1 3 2 3 3 4 dichloro phenyl 2 methoxycarbonyl 8 azabicyclo 3 2 1 oct 8 yl ethylc	0.69	1
20	bdb 1 3 di 3 4 thiophene 3 yl phenyl tropane 2 carbonylaminomethyl benzene chembl607	0.69	1
21	bdb 1 3beta 4 chloro phenyl tropane 2beta carbonyl oxy 2 4 3beta 4 chloro phenyl tro	0.69	1
22	bdb 1 3beta 4 chloro phenyl tropane 2beta carbonyl oxy 6 4 3beta 4 chloro phenyl tro	0.69	1
23	bdb 1 3beta 4 chloro phenyl tropane 2beta carbonyl oxy 7 4 3beta 4 chloro phenyl tro	0.69	1
24	bdb 1 3beta 4 chlorophenyl tropane 2beta carbonyl amino 1 3beta 4 chlorophenyl tropa	0.69	1
25	bdb 1 3beta 4 chlorophenyl tropane 2beta carbonyl amino 2 3beta 4 chlorophenyl tropa	0.69	1
26	bdb 1 3beta 4 chlorophenyl tropane 2beta carbonyl oxy 5 1 2 3 triazol 1 yl pentane c	0.69	1
27	bdb 1 3beta 4 thiophene 3 yl phenyl tropane 2beta carbonylamino 1 3beta 4 thiophene	0.69	1
28	bdb 1 3beta 4 thiophene 3 yl phenyl tropane 2beta carbonylamino 2 3beta 4 thiophene	0.69	1
29	bdb 1 4 di 3 4 thiophene 3 yl phenyl tropane 2 carbonylaminomethyl benzene chembl595	0.69	1
30	bdb 1 4 di 3beta 4 chlorophenyl tropane 2beta carbonyl amino benzene chembl608704	0.69	1
31	bdb 1 4 di 3beta 4 thiophene 3 yl phenyl tropane 2beta carbonylamino benzene chembl6	0.69	1
32	bdb 1 6 di 3beta 4 thiophene 3 yl phenyl tropane 2beta carbonylamino hexane chembl59	0.69	1
33	bdb 1 8 di 3beta 4 thiophene 3 yl phenyl tropane 2beta carbonylamino octane chembl59	0.69	1
34	bdb 1r 2r 3s 5s 2 2 2 dibromovinyl 8 methyl 3 p tolyl 8 aza bicyclo 3 2 1 octane hyd	0.69	1
35	bdb 1r 2r 3s 5s 3 4 chlorophenyl 2 2 2 dibromovinyl 8 methyl 8 aza bicyclo 3 2 1 oct	0.69	1
36	bdb 1r 2s 3r 5r methyl 3 3 fluoro 4 methylphenyl 8 aza bicyclo 3 2 1 octane 2 carbox	0.69	1
37	bdb 1r 2s 3r 5r methyl 3 4 ethynylphenyl 8 aza bicyclo 3 2 1 octane 2 carboxylate ch	0.69	1
38	bdb 1r 2s 3r 5r methyl 3 4 iodophenyl 8 aza bicyclo 3 2 1 octane 2 carboxylate chemb	0.69	1
39	bdb 1r 2s 3r 5r methyl 3 4 vinylphenyl 8 aza bicyclo 3 2 1 octane 2 carboxylate chem	0.69	1
40	bdb 1r 2s 3r 5r methyl 3 p tolyl 8 aza bicyclo 3 2 1 octane 2 carboxylate chembl2355	0.69	1
41	bdb 1r 2s 3s 5r 3 4 methoxyphenyl 8 methyl 2 3 p tolylisoxazol 5 yl 8 aza bicyclo 3	0.69	1
42	bdb 1r 2s 3s 5r 4 acetamidophenethyl 3 4 methoxyphenyl 8 methyl 8 aza bicyclo 3 2 1	0.69	1
43	bdb 1r 2s 3s 5r 4 amino 3 5 dibromophenethyl 3 4 methoxyphenyl 8 methyl 8 aza bicycl	0.69	1
44	bdb 1r 2s 3s 5r 4 amino 3 5 diiodophenethyl 3 4 methoxyphenyl 8 methyl 8 aza bicyclo	0.69	1
45	bdb 1r 2s 3s 5r 4 amino 3 bromophenethyl 3 4 methoxyphenyl 8 methyl 8 aza bicyclo 3	0.69	1
46	bdb 1r 2s 3s 5r 4 amino 3 iodophenethyl 3 4 methoxyphenyl 8 methyl 8 aza bicyclo 3 2	0.69	1
47	bdb 1r 2s 3s 5r 4 aminophenethyl 3 4 methoxyphenyl 8 methyl 8 aza bicyclo 3 2 1 octa	0.69	1
48	bdb 1r 2s 3s 5r 4 nitrophenethyl 3 4 methoxyphenyl 8 methyl 8 aza bicyclo 3 2 1 octa	0.69	1
49	bdb 1r 2s 3s 5r cyclobutyl 3 4 methoxyphenyl 8 methyl 8 aza bicyclo 3 2 1 octane 2 c	0.69	1
50	bdb 1r 2s 3s 5r cyclopropyl 3 4 methoxyphenyl 8 methyl 8 aza bicyclo 3 2 1 octane 2	0.69	1

Showing top 50 of 283 compounds. Use the BiohacksAI search to explore all SC6A3 modulators.

About SC6A3 as a Drug Target

SC6A3 (Sodium-dependent dopamine transporter) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 283 compounds with documented SC6A3 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

SC6A3 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.