What compounds affect the Intrinsic Pathway for Apoptosis pathway?

180 compounds in the BiohacksAI corpus have documented interactions with genes in the Intrinsic Pathway for Apoptosis pathway (Reactome ID: R-HSA-109606). These compounds target 13 genes within this pathway.

What genes are in the Intrinsic Pathway for Apoptosis pathway?

The Intrinsic Pathway for Apoptosis pathway involves 13 genes. Key genes include: AKT3, BAD, BCL2L1, BCL2L11, CASP9, GSDMD, MAPK1, MAPK3, MAPK8, STAT3.

Intrinsic Pathway for Apoptosis

REACTOME PATHWAY

Reactome: R-HSA-10960613 genes180 compounds

The Intrinsic Pathway for Apoptosis pathway (Reactome ID: R-HSA-109606) involves 13 genes and is affected by 180 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AKT3 BAD BCL2L1 BCL2L11 CASP9 GSDMD MAPK1 MAPK3 MAPK8 STAT3 TP53 YWHAB YWHAG

Compounds Affecting Intrinsic Pathway for Apoptosis

#	Compound	Targets Hit	Studies
1	plumbagin [Supplementary Concept]	—	300
2	pd98059	—	7
3	sp600125	—	117
4	withaferin	—	300
5	Methylene Blue	—	200
6	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
7	Niclosamide	—	299
8	Disulfiram	—	297
9	Quercetin	—	300
10	Axitinib	—	298
11	daph	—	2
12	Loratadine	—	296
13	Clotrimazole	—	296
14	vinblastine sulfate	—	81
15	Benzalkonium Compounds	—	299
16	Idarubicin	—	299
17	Progesterone	—	299
18	2-Chloroadenosine 2-Chloroadenosine.	—	300
19	alsterpaullone	—	12
20	kenpaullone	—	8
21	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
22	Sorafenib	—	300
23	trametinib	—	296
24	Masoprocol	—	300
25	Anisomycin	—	247
26	Ethidium	—	300
27	Ethinyl Estradiol	—	300
28	Hexachlorophene	—	300
29	Azacitidine	—	298
30	Azacitidine	—	300
31	Bortezomib	—	300
32	Rotenone	—	300
33	Azathioprine	—	300
34	Cladribine	—	297
35	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
36	Cytarabine	—	297
37	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
38	Melphalan	—	300
39	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
40	Methotrexate	—	289
41	Dactinomycin	—	297
42	Daunorubicin	—	298
43	Glutaral	—	42
44	Vitamin K 3	—	300
45	Trifluridine	—	295
46	ninhydrin	—	300
47	o-Phthalaldehyde	—	300
48	Razoxane	—	154
49	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
50	Camptothecin	—	300

About the Intrinsic Pathway for Apoptosis Pathway

The Intrinsic Pathway for Apoptosis pathway is catalogued in Reactome (ID: R-HSA-109606) and involves 13 genes. In the BiohacksAI corpus, 180 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AKT3, BAD, BCL2L1, BCL2L11, CASP9.