What compounds affect the Ca-dependent events pathway?

95 compounds in the BiohacksAI corpus have documented interactions with genes in the Ca-dependent events pathway (Reactome ID: R-HSA-111996). These compounds target 15 genes within this pathway.

What genes are in the Ca-dependent events pathway?

The Ca-dependent events pathway involves 15 genes. Key genes include: ADCY9, CAMK2B, CAMK2D, CAMKK1, CAMKK2, CREB1, GRK2, MAPK1, PDE1A, PDE1B.

Ca-dependent events

REACTOME PATHWAY

Reactome: R-HSA-11199615 genes95 compounds

The Ca-dependent events pathway (Reactome ID: R-HSA-111996) involves 15 genes and is affected by 95 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADCY9 CAMK2B CAMK2D CAMKK1 CAMKK2 CREB1 GRK2 MAPK1 PDE1A PDE1B PDE1C PRKACA PRKACB PRKACG PRKX

Compounds Affecting Ca-dependent events

#	Compound	Targets Hit	Studies
1	sp600125	—	117
2	hydroxyfasudil [Supplementary Concept]	—	11
3	vinpocetine	—	299
4	Papaverine	—	299
5	Disulfiram	—	297
6	trequinsin hydrochloride	—	1
7	Quercetin	—	300
8	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
9	alsterpaullone	—	12
10	Sorafenib	—	300
11	Aurintricarboxylic Acid	—	184
12	KN 92 [Supplementary Concept] KN 93 isomer;	—	26
13	Axitinib	—	298
14	cycloheximide	—	300
15	Azacitidine	—	298
16	Azacitidine	—	300
17	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
18	Levalbuterol	—	1,000
19	Adenosine Monophosphate Adenine nucleotide containing	—	300
20	Levalbuterol	—	297
21	Bortezomib	—	300
22	Clofarabine	—	298
23	Dactinomycin	—	297
24	Danazol	—	298
25	Emetine	—	298
26	Ethidium	—	300
27	Isopentenyladenosine N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is	—	270
28	Sulbactam	—	299
29	chrysin	—	300
30	Genistein	—	300
31	Testosterone	—	299
32	Ciclopirox	—	88
33	Cladribine	—	297
34	Clenbuterol	—	300
35	Corticosterone	—	300
36	Dasatinib	—	299
37	Daunorubicin	—	298
38	Dinoprostone	—	296
39	Epinephrine	—	299
40	Ethinyl Estradiol	—	300
41	Imatinib Mesylate	—	300
42	Nisoldipine	—	297
43	Nocodazole Nocodazole is	—	215
44	Masoprocol	—	300
45	Norepinephrine Precursor of epinephrine that is secreted by	—	298
46	o-Phthalaldehyde	—	300
47	Oxyphenbutazone	—	300
48	pivampicillin	—	275
49	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
50	Salmeterol Xinafoate	—	227

About the Ca-dependent events Pathway

The Ca-dependent events pathway is catalogued in Reactome (ID: R-HSA-111996) and involves 15 genes. In the BiohacksAI corpus, 95 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADCY9, CAMK2B, CAMK2D, CAMKK1, CAMKK2.