What compounds affect the G-protein mediated events pathway?

112 compounds in the BiohacksAI corpus have documented interactions with genes in the G-protein mediated events pathway (Reactome ID: R-HSA-112040). These compounds target 18 genes within this pathway.

What genes are in the G-protein mediated events pathway?

The G-protein mediated events pathway involves 18 genes. Key genes include: ADCY9, CAMK2B, CAMK2D, CAMKK1, CAMKK2, CREB1, GNA15, GNAI1, GRK2, MAPK1.

G-protein mediated events

REACTOME PATHWAY

Reactome: R-HSA-11204018 genes112 compounds

The G-protein mediated events pathway (Reactome ID: R-HSA-112040) involves 18 genes and is affected by 112 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADCY9 CAMK2B CAMK2D CAMKK1 CAMKK2 CREB1 GNA15 GNAI1 GRK2 MAPK1 PDE1A PDE1B PDE1C PLCB3 PRKACA PRKACB PRKACG PRKX

Compounds Affecting G-protein mediated events

#	Compound	Targets Hit	Studies
1	sp600125	—	117
2	hydroxyfasudil [Supplementary Concept]	—	11
3	Aurintricarboxylic Acid	—	184
4	vinpocetine	—	299
5	Papaverine	—	299
6	Disulfiram	—	297
7	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
8	Ethidium	—	300
9	trequinsin hydrochloride	—	1
10	Quercetin	—	300
11	Daunorubicin	—	298
12	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
13	tyrphostin ag 1478	—	4
14	alsterpaullone	—	12
15	Calcimycin	—	216
16	Sorafenib	—	300
17	Riboflavin Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables.	—	297
18	Cefixime	—	300
19	Sphingosine	—	300
20	KN 92 [Supplementary Concept] KN 93 isomer;	—	26
21	Axitinib	—	298
22	cycloheximide	—	300
23	Azacitidine	—	298
24	Azacitidine	—	300
25	Levalbuterol	—	1,000
26	Adenosine Monophosphate Adenine nucleotide containing	—	300
27	Levalbuterol	—	297
28	Bortezomib	—	300
29	Clofarabine	—	298
30	Dactinomycin	—	297
31	Danazol	—	298
32	Emetine	—	298
33	Isopentenyladenosine N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is	—	270
34	Sulbactam	—	299
35	chrysin	—	300
36	Genistein	—	300
37	Testosterone	—	299
38	Ciclopirox	—	88
39	Cladribine	—	297
40	Clenbuterol	—	300
41	Corticosterone	—	300
42	Dasatinib	—	299
43	Dinoprostone	—	296
44	Epinephrine	—	299
45	Ethinyl Estradiol	—	300
46	Imatinib Mesylate	—	300
47	Nisoldipine	—	297
48	Nocodazole Nocodazole is	—	215
49	Masoprocol	—	300
50	Norepinephrine Precursor of epinephrine that is secreted by	—	298

About the G-protein mediated events Pathway

The G-protein mediated events pathway is catalogued in Reactome (ID: R-HSA-112040) and involves 18 genes. In the BiohacksAI corpus, 112 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADCY9, CAMK2B, CAMK2D, CAMKK1, CAMKK2.