Synthesis of bile acids and bile salts via 27-hydroxycholesterol

Q: What compounds affect the Synthesis of bile acids and bile salts via 27-hydroxycholesterol pathway?

128 compounds in the BiohacksAI corpus have documented interactions with genes in the Synthesis of bile acids and bile salts via 27-hydroxycholesterol pathway (Reactome ID: R-HSA-193807). These compounds target 8 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-1938078 genes128 compounds

The Synthesis of bile acids and bile salts via 27-hydroxycholesterol pathway (Reactome ID: R-HSA-193807) involves 8 genes and is affected by 128 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AKR1C1 AKR1C2 AKR1C3 AKR1C4 CYP8B1 NCOA1 NR1H4 RXRA

Compounds Affecting Synthesis of bile acids and bile salts via 27-hydroxycholesterol

#	Compound	Targets Hit	Studies
1	Progesterone	—	299
2	Medroxyprogesterone Acetate	—	299
3	Genistein	—	300
4	Ethidium	—	300
5	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
6	Rotenone	—	300
7	Methylene Blue	—	200
8	Clotrimazole	—	296
9	Dactinomycin	—	297
10	chrysin	—	300
11	Thyroxine	—	994
12	Methotrexate	—	289
13	Azacitidine	—	298
14	Azacitidine	—	300
15	Dihydrotestosterone	—	300
16	Retinaldehyde	—	300
17	Thyroxine	—	300
18	Testosterone	—	299
19	Naproxen	—	1,000
20	Berberine	—	300
21	Chenodeoxycholic Acid	—	299
22	obeticholic acid [Supplementary Concept]	—	271
23	Ursodeoxycholic Acid	—	298
24	Cholic Acid	—	299
25	Lithocholic Acid	—	300
26	Resveratrol	—	298
27	Ethinyl Estradiol	—	300
28	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
29	Colchicine	—	300
30	Chlormadinone Acetate	—	300
31	Daunorubicin	—	298
32	Decitabine	—	298
33	Finasteride	—	296
34	Fulvestrant	—	295
35	Itraconazole	—	297
36	Mometasone Furoate	—	292
37	Podophyllotoxin	—	14
38	trequinsin hydrochloride	—	1
39	vinblastine sulfate	—	81
40	Atorvastatin	—	1,000
41	Dehydroepiandrosterone	—	300
42	Simvastatin	—	1,000
43	Adapalene	—	296
44	Chlorhexidine	—	299
45	Deferasirox	—	298
46	Dehydroepiandrosterone	—	300
47	Dinitrochlorobenzene	—	300
48	Emetine	—	298
49	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
50	Estramustine	—	300

About the Synthesis of bile acids and bile salts via 27-hydroxycholesterol Pathway

The Synthesis of bile acids and bile salts via 27-hydroxycholesterol pathway is catalogued in Reactome (ID: R-HSA-193807) and involves 8 genes. In the BiohacksAI corpus, 128 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AKR1C1, AKR1C2, AKR1C3, AKR1C4, CYP8B1.