What compounds affect the Signaling by ALK pathway?

86 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by ALK pathway (Reactome ID: R-HSA-201556). These compounds target 15 genes within this pathway.

What genes are in the Signaling by ALK pathway?

The Signaling by ALK pathway involves 15 genes. Key genes include: ALK, DNMT1, EP300, HDAC1, HDAC2, HDAC3, HIF1A, JAK3, MYC, PIK3CB.

Signaling by ALK

REACTOME PATHWAY

Reactome: R-HSA-20155615 genes86 compounds

The Signaling by ALK pathway (Reactome ID: R-HSA-201556) involves 15 genes and is affected by 86 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ALK DNMT1 EP300 HDAC1 HDAC2 HDAC3 HIF1A JAK3 MYC PIK3CB PIK3R1 PIK3R2 PTPN6 SRC STAT3

Compounds Affecting Signaling by ALK

#	Compound	Targets Hit	Studies
1	pictilisib	—	25
2	Bortezomib	—	300
3	Quercetin	—	300
4	Camptothecin	—	300
5	Celecoxib	—	295
6	egcg	—	300
7	Resveratrol	—	298
8	Niclosamide	—	299
9	Sorafenib	—	300
10	Crizotinib	—	298
11	Vorinostat	—	299
12	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
13	scriptaid	—	53
14	Valproic Acid	—	296
15	Butyric Acid	—	300
16	Ursolic Acid	—	300
17	Daunorubicin	—	298
18	ly294002	—	11
19	Sirolimus	—	300
20	cycloheximide	—	300
21	celastrol	—	300
22	Oxytetracycline	—	300
23	sp600125	—	117
24	Wortmannin	—	300
25	alpelisib	—	227
26	Emetine	—	298
27	Topotecan	—	300
28	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	—	76
29	Gliotoxin	—	300
30	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
31	Harmaline	—	300
32	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
33	Loratadine	—	296
34	oxatomide [Supplementary Concept] structure;	—	128
35	triolimus [Supplementary Concept]	—	33
36	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
37	chrysin	—	300
38	Hydrocortisone	—	299
39	Kaempferols	—	300
40	2-Chloroadenosine 2-Chloroadenosine.	—	300
41	ag490	—	14
42	Beclomethasone	—	300
43	Clotrimazole	—	296
44	cycloserine	—	298
45	Dequalinium	—	136
46	Desoximetasone	—	86
47	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
48	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
49	Digoxin	—	299
50	Epinephrine	—	299

About the Signaling by ALK Pathway

The Signaling by ALK pathway is catalogued in Reactome (ID: R-HSA-201556) and involves 15 genes. In the BiohacksAI corpus, 86 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ALK, DNMT1, EP300, HDAC1, HDAC2.