What genes are in the Epigenetic regulation of gene expression pathway?

The Epigenetic regulation of gene expression pathway involves 45 genes. Key genes include: ABL1, ASH2L, CCNC, CDK5, CDK7, CDK8, CREBBP, DNMT1, DNMT3B, DPY30.

Epigenetic regulation of gene expression

Q: What compounds affect the Epigenetic regulation of gene expression pathway?

230 compounds in the BiohacksAI corpus have documented interactions with genes in the Epigenetic regulation of gene expression pathway (Reactome ID: R-HSA-212165). These compounds target 45 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-21216545 genes230 compounds

The Epigenetic regulation of gene expression pathway (Reactome ID: R-HSA-212165) involves 45 genes and is affected by 230 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 ASH2L CCNC CDK5 CDK7 CDK8 CREBBP DNMT1 DNMT3B DPY30 EED EHMT1 EHMT2 EP300 ERCC3 EZH1 EZH2 FABP4 GSK3B HDAC1 HDAC2 HDAC3 KAT2A KAT2B KMT2A MBD2 MEN1 MGLL MPHOSPH8 NCOA1+15 more

Compounds Affecting Epigenetic regulation of gene expression

#	Compound	Targets Hit	Studies
1	s adenosylhomocysteine	—	300
2	Methylene Blue	—	200
3	Sorafenib	—	300
4	Disulfiram	—	297
5	Ethidium	—	300
6	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
7	Quercetin	—	300
8	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
9	alsterpaullone	—	12
10	Methotrexate	—	289
11	Biotin	—	297
12	Azacitidine	—	298
13	Azacitidine	—	300
14	egcg	—	300
15	Vorinostat	—	299
16	Genistein	—	300
17	chrysin	—	300
18	Arachidonic Acid	—	245
19	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
20	Oleic Acid	—	112
21	cycloheximide	—	300
22	Daunorubicin	—	298
23	Levodopa	—	297
24	kenpaullone	—	8
25	Ursolic Acid	—	300
26	Cefixime	—	300
27	scriptaid	—	53
28	pictilisib	—	25
29	urolithin b	—	49
30	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
31	Edaravone	—	298
32	Nocodazole Nocodazole is	—	215
33	Anthraquinones Compounds based on ANTHRACENES which contain two KETONES in	—	300
34	Aurintricarboxylic Acid	—	184
35	Methyldopa	—	297
36	tyrphostin 9	—	2
37	Anisomycin	—	247
38	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
39	Digoxin	—	299
40	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	—	115
41	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
42	Tubercidin	—	300
43	Oxytetracycline	—	300
44	DEAD-box RNA Helicases	—	169
45	Thioctic Acid	—	298
46	Thioctic Acid	—	300
47	Ampicillin Semi-synthetic derivative of penicillin that functions as	—	294
48	Demeclocycline	—	5
49	hydroxyfasudil [Supplementary Concept]	—	11
50	Valproic Acid	—	296

About the Epigenetic regulation of gene expression Pathway

The Epigenetic regulation of gene expression pathway is catalogued in Reactome (ID: R-HSA-212165) and involves 45 genes. In the BiohacksAI corpus, 230 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, ASH2L, CCNC, CDK5, CDK7.