Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)

Q: What compounds affect the Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) pathway?

492 compounds in the BiohacksAI corpus have documented interactions with genes in the Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) pathway (Reactome ID: R-HSA-2142670). These compounds target 8 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-21426708 genes492 compounds

The Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) pathway (Reactome ID: R-HSA-2142670) involves 8 genes and is affected by 492 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CYP1A1 CYP1A2 CYP1B1 CYP2C19 CYP2C8 CYP2C9 CYP2J2 EPHX2

Compounds Affecting Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
3	chrysin	—	300
4	Kaempferols	—	300
5	Hesperidin	—	300
6	cbd	—	298
7	cannabidiol	—	296
8	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
9	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
10	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
11	Clotrimazole	—	296
12	Danazol	—	298
13	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
14	Gemfibrozil	—	297
15	Miconazole	—	298
16	Kaempferols	—	300
17	Disulfiram	—	297
18	Isoniazid Antibacterial agent used primarily as	—	299
19	Ethinyl Estradiol	—	300
20	Flutamide	—	298
21	Methoxsalen	—	300
22	Rotenone	—	300
23	Carbaryl	—	300
24	Chlorhexidine	—	299
25	Corticosterone	—	300
26	Ethoxyquin Antioxidant; also	—	180
27	Fulvestrant	—	295
28	Loratadine	—	296
29	Vitamin K 3	—	300
30	Piribedil	—	300
31	Tolazamide	—	169
32	Genistein	—	300
33	Progesterone	—	299
34	Fenofibrate	—	297
35	Mestranol	—	300
36	Nisoldipine	—	297
37	Sulindac	—	297
38	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
39	Pueraria	—	300
40	Melatonin	—	297
41	Methylene Blue	—	200
42	Vitamin	—	295
43	Anastrozole	—	298
44	Carboxin	—	174
45	Ethidium	—	300
46	iodoform	—	272
47	Leflunomide	—	297
48	Linuron	—	299
49	Lynestrenol	—	299
50	Melphalan	—	300

About the Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Pathway

The Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) pathway is catalogued in Reactome (ID: R-HSA-2142670) and involves 8 genes. In the BiohacksAI corpus, 492 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8.