What genes are in the Senescence-Associated Secretory Phenotype (SASP) pathway?

The Senescence-Associated Secretory Phenotype (SASP) pathway involves 19 genes. Key genes include: CCNA1, CDK2, CDK4, CDK6, CXCL8, EHMT1, EHMT2, FOS, IL6, JUN.

Senescence-Associated Secretory Phenotype (SASP)

Q: What compounds affect the Senescence-Associated Secretory Phenotype (SASP) pathway?

145 compounds in the BiohacksAI corpus have documented interactions with genes in the Senescence-Associated Secretory Phenotype (SASP) pathway (Reactome ID: R-HSA-2559582). These compounds target 19 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-255958219 genes145 compounds

The Senescence-Associated Secretory Phenotype (SASP) pathway (Reactome ID: R-HSA-2559582) involves 19 genes and is affected by 145 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CCNA1 CDK2 CDK4 CDK6 CXCL8 EHMT1 EHMT2 FOS IL6 JUN MAPK1 MAPK3 MAPK7 NFKB1 RELA RPS6KA1 RPS6KA2 RPS6KA3 STAT3

Compounds Affecting Senescence-Associated Secretory Phenotype (SASP)

#	Compound	Targets Hit	Studies
1	sp600125	—	117
2	fisetin	—	78
3	Disulfiram	—	297
4	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
5	withaferin	—	300
6	alsterpaullone	—	12
7	kenpaullone	—	8
8	Sorafenib	—	300
9	Podophyllotoxin	—	14
10	ninhydrin	—	300
11	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
12	Kaempferols	—	300
13	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
14	plumbagin [Supplementary Concept]	—	300
15	Colchicine	—	300
16	Diphenhydramine	—	14
17	vinblastine sulfate	—	81
18	egcg	—	300
19	Lithocholic Acid	—	300
20	Lovastatin	—	300
21	Promethazine	—	121
22	Clotrimazole	—	296
23	Cyproheptadine	—	299
24	Masoprocol	—	300
25	Toxaphene	—	299
26	Quercetin	—	300
27	Resveratrol	—	298
28	Bortezomib	—	300
29	Rutin	—	300
30	Withania	—	500
31	daph	—	2
32	tamarixetin	—	26
33	Trifluridine	—	295
34	tyrphostin ag 1478	—	4
35	pd98059	—	7
36	trametinib	—	296
37	s adenosylhomocysteine	—	300
38	Glutathione	—	300
39	Anthraquinones Compounds based on ANTHRACENES which contain two KETONES in	—	300
40	Dimethyl Sulfoxide	—	300
41	hydroxyfasudil [Supplementary Concept]	—	11
42	indirubin	—	300
43	DEAD-box RNA Helicases	—	169
44	Thioctic Acid	—	298
45	glaucarubinone	—	10
46	Thioctic Acid	—	300
47	Methylene Blue	—	200
48	Amoxapine	—	259
49	Cinnarizine	—	299
50	Clofibrate	—	299

About the Senescence-Associated Secretory Phenotype (SASP) Pathway

The Senescence-Associated Secretory Phenotype (SASP) pathway is catalogued in Reactome (ID: R-HSA-2559582) and involves 19 genes. In the BiohacksAI corpus, 145 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CCNA1, CDK2, CDK4, CDK6, CXCL8.