What compounds affect the FCERI mediated MAPK activation pathway?

264 compounds in the BiohacksAI corpus have documented interactions with genes in the FCERI mediated MAPK activation pathway (Reactome ID: R-HSA-2871796). These compounds target 13 genes within this pathway.

What genes are in the FCERI mediated MAPK activation pathway?

The FCERI mediated MAPK activation pathway involves 13 genes. Key genes include: FOS, GRB2, JUN, LAT, LYN, MAP2K4, MAP3K1, MAPK1, MAPK10, MAPK3.

FCERI mediated MAPK activation

REACTOME PATHWAY

Reactome: R-HSA-287179613 genes264 compounds

The FCERI mediated MAPK activation pathway (Reactome ID: R-HSA-2871796) involves 13 genes and is affected by 264 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

FOS GRB2 JUN LAT LYN MAP2K4 MAP3K1 MAPK1 MAPK10 MAPK3 MAPK8 MAPK9 SYK

Compounds Affecting FCERI mediated MAPK activation

#	Compound	Targets Hit	Studies
1	sp600125	—	117
2	Sorafenib	—	300
3	pictilisib	—	25
4	alsterpaullone	—	12
5	kenpaullone	—	8
6	Crizotinib	—	298
7	tyrphostin ag 1478	—	4
8	fisetin	—	78
9	Axitinib	—	298
10	withaferin	—	300
11	Afatinib	—	297
12	Clotrimazole	—	296
13	pd98059	—	7
14	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
15	Anisomycin	—	247
16	Dasatinib	—	299
17	Colchicine	—	300
18	Disulfiram	—	297
19	Lovastatin	—	300
20	Medroxyprogesterone Acetate	—	299
21	Podophyllotoxin	—	14
22	Maprotiline	—	299
23	Nocodazole Nocodazole is	—	215
24	Vincristine	—	299
25	Methylene Blue	—	200
26	Sertraline	—	1,000
27	Ethynodiol Diacetate	—	300
28	Lumefantrine	—	299
29	Vitamin K 3	—	300
30	Nisoldipine	—	297
31	Rotenone	—	300
32	trequinsin hydrochloride	—	1
33	Vemurafenib	—	298
34	vinblastine sulfate	—	81
35	Fluoxetine	—	1,000
36	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
37	Quercetin	—	300
38	vinpocetine	—	299
39	Amoxapine	—	259
40	Chlormadinone Acetate	—	300
41	Cyproheptadine	—	299
42	daph	—	2
43	Domperidone	—	299
44	eliprodil	—	33
45	Gemfibrozil	—	297
46	Loratadine	—	296
47	Mestranol	—	300
48	propionylpromazine hydrochloride	—	2
49	Stanozolol	—	300
50	Diphenhydramine	—	14

About the FCERI mediated MAPK activation Pathway

The FCERI mediated MAPK activation pathway is catalogued in Reactome (ID: R-HSA-2871796) and involves 13 genes. In the BiohacksAI corpus, 264 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include FOS, GRB2, JUN, LAT, LYN.