What compounds affect the FCERI mediated Ca+2 mobilization pathway?

203 compounds in the BiohacksAI corpus have documented interactions with genes in the FCERI mediated Ca+2 mobilization pathway (Reactome ID: R-HSA-2871809). These compounds target 6 genes within this pathway.

What genes are in the FCERI mediated Ca+2 mobilization pathway?

The FCERI mediated Ca+2 mobilization pathway involves 6 genes. Key genes include: BTK, GRB2, ITK, LAT, LYN, SYK.

FCERI mediated Ca+2 mobilization

REACTOME PATHWAY

Reactome: R-HSA-28718096 genes203 compounds

The FCERI mediated Ca+2 mobilization pathway (Reactome ID: R-HSA-2871809) involves 6 genes and is affected by 203 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

BTK GRB2 ITK LAT LYN SYK

Compounds Affecting FCERI mediated Ca+2 mobilization

#	Compound	Targets Hit	Studies
1	Crizotinib	—	298
2	Dasatinib	—	299
3	tyrphostin ag 1478	—	4
4	sp600125	—	117
5	Axitinib	—	298
6	Sorafenib	—	300
7	alsterpaullone	—	12
8	kenpaullone	—	8
9	Ouabain	—	300
10	Atorvastatin	—	1,000
11	Simvastatin	—	1,000
12	Methotrexate	—	289
13	Chlorhexidine	—	299
14	Clofarabine	—	298
15	Colchicine	—	300
16	cycloheximide	—	300
17	deguelin [Supplementary Concept]	—	151
18	Digoxin	—	299
19	Disulfiram	—	297
20	Emetine	—	298
21	Ezetimibe	—	296
22	Lovastatin	—	300
23	Medroxyprogesterone Acetate	—	299
24	Melphalan	—	300
25	Mometasone Furoate	—	292
26	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
27	Niclosamide	—	299
28	piceatannol	—	300
29	Podophyllotoxin	—	14
30	Thapsigargin	—	300
31	torin 1	—	10
32	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
33	Trifluridine	—	295
34	fisetin	—	78
35	ag490	—	14
36	alpelisib	—	227
37	Azathioprine	—	300
38	Bortezomib	—	300
39	Maprotiline	—	299
40	Nocodazole Nocodazole is	—	215
41	N-pyridazin-3-yl-4-(3-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzylidene)piperidine-1-carboxamide [Supplementary Concept]	—	8
42	Tripterygium	—	300
43	Vincristine	—	299
44	withaferin	—	300
45	Berberine	—	300
46	cbd	—	298
47	Doxycycline	—	999
48	Methylene Blue	—	200
49	Minocycline	—	297
50	Sertraline	—	1,000

About the FCERI mediated Ca+2 mobilization Pathway

The FCERI mediated Ca+2 mobilization pathway is catalogued in Reactome (ID: R-HSA-2871809) and involves 6 genes. In the BiohacksAI corpus, 203 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BTK, GRB2, ITK, LAT, LYN.