What compounds affect the Cellular response to heat stress pathway?

118 compounds in the BiohacksAI corpus have documented interactions with genes in the Cellular response to heat stress pathway (Reactome ID: R-HSA-3371556). These compounds target 24 genes within this pathway.

What genes are in the Cellular response to heat stress pathway?

The Cellular response to heat stress pathway involves 24 genes. Key genes include: ATM, CAMK2B, CAMK2D, CREBBP, CRYAB, EP300, FKBP4, GSK3B, HDAC6, HSP90AA1.

Cellular response to heat stress

REACTOME PATHWAY

Reactome: R-HSA-337155624 genes118 compounds

The Cellular response to heat stress pathway (Reactome ID: R-HSA-3371556) involves 24 genes and is affected by 118 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ATM CAMK2B CAMK2D CREBBP CRYAB EP300 FKBP4 GSK3B HDAC6 HSP90AA1 HSP90AB1 HSPA1A HSPA1B HSPA5 HSPA8 MAPK1 MAPK3 MAPKAPK2 MLST8 MTOR PTGES3 RPTOR SIRT1 VCP

Compounds Affecting Cellular response to heat stress

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	sp600125	—	117
3	Hexachlorophene	—	300
4	Sirolimus	—	300
5	Everolimus	—	297
6	egcg	—	300
7	alsterpaullone	—	12
8	Sorafenib	—	300
9	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300
10	Ergosterol	—	300
11	Ursolic Acid	—	300
12	fisetin	—	78
13	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
14	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
15	pd98059	—	7
16	piceatannol	—	300
17	triolimus [Supplementary Concept]	—	33
18	gedunin	—	54
19	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
20	Calcimycin	—	216
21	Clotrimazole	—	296
22	Idarubicin	—	299
23	torin 1	—	10
24	Ku 0063794 [Supplementary Concept]	—	7
25	plumbagin [Supplementary Concept]	—	300
26	kenpaullone	—	8
27	Adenosine Triphosphate	—	300
28	pictilisib	—	25
29	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
30	chrysin	—	300
31	Kaempferols	—	300
32	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
33	Camptothecin	—	300
34	monorden	—	8
35	celastrol	—	300
36	Novobiocin	—	300
37	caffeic acid	—	300
38	Masoprocol	—	300
39	Tetracycline	—	300
40	2-Chloroadenosine 2-Chloroadenosine.	—	300
41	ag490	—	14
42	Disulfiram	—	297
43	Nitroprusside	—	299
44	Wortmannin	—	300
45	ly294002	—	11
46	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
47	trametinib	—	296
48	withaferin	—	300
49	KN 92 [Supplementary Concept] KN 93 isomer;	—	26
50	Vorinostat	—	299

About the Cellular response to heat stress Pathway

The Cellular response to heat stress pathway is catalogued in Reactome (ID: R-HSA-3371556) and involves 24 genes. In the BiohacksAI corpus, 118 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ATM, CAMK2B, CAMK2D, CREBBP, CRYAB.