What compounds affect the NCAM signaling for neurite out-growth pathway?

109 compounds in the BiohacksAI corpus have documented interactions with genes in the NCAM signaling for neurite out-growth pathway (Reactome ID: R-HSA-375165). These compounds target 15 genes within this pathway.

What genes are in the NCAM signaling for neurite out-growth pathway?

The NCAM signaling for neurite out-growth pathway involves 15 genes. Key genes include: CACNA1C, CACNA1D, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CREB1, FGFR1, FYN, GRB2.

NCAM signaling for neurite out-growth

REACTOME PATHWAY

Reactome: R-HSA-37516515 genes109 compounds

The NCAM signaling for neurite out-growth pathway (Reactome ID: R-HSA-375165) involves 15 genes and is affected by 109 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CACNA1C CACNA1D CACNA1G CACNA1H CACNA1I CACNA1S CREB1 FGFR1 FYN GRB2 MAPK1 MAPK3 PRNP RPS6KA5 SRC

Compounds Affecting NCAM signaling for neurite out-growth

#	Compound	Targets Hit	Studies
1	Dasatinib	—	299
2	Sorafenib	—	300
3	Nisoldipine	—	297
4	Astemizole Antihistamine drug now withdrawn from	—	280
5	alsterpaullone	—	12
6	kenpaullone	—	8
7	Nitrendipine	—	299
8	Quinidine	—	298
9	Duloxetine Hydrochloride	—	993
10	Crizotinib	—	298
11	tyrphostin ag 1478	—	4
12	sp600125	—	117
13	Flunarizine Flunarizine is	—	299
14	cycloheximide	—	300
15	Azacitidine	—	298
16	Azacitidine	—	300
17	Adenosine Monophosphate Adenine nucleotide containing	—	300
18	Dactinomycin	—	297
19	Danazol	—	298
20	trequinsin hydrochloride	—	1
21	Genistein	—	300
22	Quercetin	—	300
23	Testosterone	—	299
24	Amlodipine	—	1,000
25	Clotrimazole	—	296
26	plumbagin [Supplementary Concept]	—	300
27	pd98059	—	7
28	Calcimycin	—	216
29	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
30	Loratadine	—	296
31	trametinib	—	296
32	withaferin	—	300
33	Hexachlorophene	—	300
34	Disulfiram	—	297
35	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
36	Levalbuterol	—	1,000
37	Levalbuterol	—	297
38	Bortezomib	—	300
39	Clofarabine	—	298
40	Emetine	—	298
41	Ethidium	—	300
42	Isopentenyladenosine N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is	—	270
43	Sulbactam	—	299
44	chrysin	—	300
45	Ciclopirox	—	88
46	Cladribine	—	297
47	Clenbuterol	—	300
48	Corticosterone	—	300
49	Daunorubicin	—	298
50	Dinoprostone	—	296

About the NCAM signaling for neurite out-growth Pathway

The NCAM signaling for neurite out-growth pathway is catalogued in Reactome (ID: R-HSA-375165) and involves 15 genes. In the BiohacksAI corpus, 109 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CACNA1C, CACNA1D, CACNA1G, CACNA1H, CACNA1I.