What compounds affect the Muscarinic acetylcholine receptors pathway?

159 compounds in the BiohacksAI corpus have documented interactions with genes in the Muscarinic acetylcholine receptors pathway (Reactome ID: R-HSA-390648). These compounds target 5 genes within this pathway.

What genes are in the Muscarinic acetylcholine receptors pathway?

The Muscarinic acetylcholine receptors pathway involves 5 genes. Key genes include: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5.

Muscarinic acetylcholine receptors

REACTOME PATHWAY

Reactome: R-HSA-3906485 genes159 compounds

The Muscarinic acetylcholine receptors pathway (Reactome ID: R-HSA-390648) involves 5 genes and is affected by 159 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CHRM1 CHRM2 CHRM3 CHRM4 CHRM5

Compounds Affecting Muscarinic acetylcholine receptors

#	Compound	Targets Hit	Studies
1	Hyoscyamine	—	296
2	Arecoline	—	299
3	Pilocarpine	—	297
4	N-Methylscopolamine	—	299
5	Scopolamine	—	298
6	Quetiapine Fumarate	—	994
7	Muscarine	—	299
8	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
9	Cyproheptadine	—	299
10	Hyoscyamine	—	296
11	hexahydrosiladiphenidol	—	1
12	Strychnine	—	300
13	Butaclamol	—	300
14	Tilorone	—	300
15	Amoxapine	—	259
16	Maprotiline	—	299
17	Ipratropium	—	297
18	Loxapine	—	225
19	Nortriptyline	—	295
20	Mianserin	—	299
21	Dimethindene	—	119
22	Tolterodine Tartrate	—	73
23	Vincamine	—	300
24	Astemizole Antihistamine drug now withdrawn from	—	280
25	Promethazine	—	121
26	Diphenhydramine	—	14
27	Propantheline	—	73
28	Perphenazine	—	297
29	Promazine	—	40
30	Promethazine	—	296
31	Thioridazine	—	35
32	Butylscopolammonium Bromide Antimuscarinic quaternary ammonium derivative of scopolamine used to treat cramps in gastrointestinal, urinary, uterine, and biliary tracts, and to facilitate radiologic visualization of	—	33
33	Loxapine	—	30
34	mg624	—	3
35	Nortriptyline	—	28
36	triflupromazine hydrochloride	—	12
37	Metergoline	—	144
38	oxatomide [Supplementary Concept] structure;	—	128
39	propionylpromazine hydrochloride	—	2
40	protriptyline	—	296
41	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
42	Vemurafenib	—	298
43	Chlorpheniramine	—	298
44	chlorprothixene hydrochloride	—	1
45	Loratadine	—	296
46	Chlorhexidine	—	299
47	Nicergoline	—	300
48	Aripiprazole	—	298
49	dilazep	—	300
50	dofetilide	—	298

About the Muscarinic acetylcholine receptors Pathway

The Muscarinic acetylcholine receptors pathway is catalogued in Reactome (ID: R-HSA-390648) and involves 5 genes. In the BiohacksAI corpus, 159 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CHRM1, CHRM2, CHRM3, CHRM4, CHRM5.