Adrenaline signalling through Alpha-2 adrenergic receptor

Q: What compounds affect the Adrenaline signalling through Alpha-2 adrenergic receptor pathway?

112 compounds in the BiohacksAI corpus have documented interactions with genes in the Adrenaline signalling through Alpha-2 adrenergic receptor pathway (Reactome ID: R-HSA-392023). These compounds target 3 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-3920233 genes112 compounds

The Adrenaline signalling through Alpha-2 adrenergic receptor pathway (Reactome ID: R-HSA-392023) involves 3 genes and is affected by 112 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRA2A ADRA2B ADRA2C

Compounds Affecting Adrenaline signalling through Alpha-2 adrenergic receptor

#	Compound	Targets Hit	Studies
1	Yohimbine	—	299
2	Clonidine	—	299
3	Oxymetazoline	—	298
4	Norepinephrine Precursor of epinephrine that is secreted by	—	298
5	Phentolamine	—	300
6	Idazoxan	—	300
7	Epinephrine	—	299
8	Phenylephrine	—	299
9	Mianserin	—	299
10	Dexmedetomidine	—	299
11	Rilmenidine Oxazole derivative that acts as	—	300
12	Naphazoline	—	298
13	Piperoxan	—	167
14	Aripiprazole	—	298
15	Bromocriptine	—	299
16	Cabergoline	—	299
17	Dihydroergotamine	—	299
18	Guanfacine	—	294
19	Pergolide	—	299
20	Tolazoline	—	300
21	Carvedilol	—	296
22	Tamsulosin	—	298
23	Fluoxetine	—	1,000
24	Quetiapine Fumarate	—	994
25	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
26	Lisuride	—	299
27	Dihydroergotamine	—	9
28	Guanabenz	—	298
29	Loxapine	—	225
30	Metergoline	—	144
31	Metoclopramide	—	297
32	Phenoxybenzamine	—	21
33	Piribedil	—	300
34	Pramipexole	—	297
35	Promethazine	—	296
36	Trazodone	—	297
37	Amisulpride	—	298
38	Amoxapine	—	259
39	Buspirone	—	299
40	Chlorhexidine	—	299
41	Dihydroergocornine	—	65
42	Ergotamine	—	299
43	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
44	Indoramin	—	250
45	lidoflazine	—	278
46	Maprotiline	—	299
47	Methoxamine	—	300
48	Methysergide	—	300
49	Nebivolol	—	297
50	Nortriptyline	—	295

About the Adrenaline signalling through Alpha-2 adrenergic receptor Pathway

The Adrenaline signalling through Alpha-2 adrenergic receptor pathway is catalogued in Reactome (ID: R-HSA-392023) and involves 3 genes. In the BiohacksAI corpus, 112 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRA2A, ADRA2B, ADRA2C.